Early adversity and insulin: neuroendocrine programming beyond glucocorticoids.
brain
early adversity
executive function
insulin
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
16
07
2021
revised:
07
09
2021
accepted:
10
09
2021
pubmed:
13
10
2021
medline:
28
4
2022
entrez:
12
10
2021
Statut:
ppublish
Résumé
Exposure to direct or contextual adversities during early life programs the functioning of the brain and other biological systems, contributing to the development of physical as well as mental health issues in the long term. While the role of glucocorticoids in mediating the outcomes of early adversity has been explored for many years, less attention has been given to insulin. Beyond its metabolic effects in the periphery, central insulin action affects synaptic plasticity, brain neurotransmission, and executive functions. Knowledge about the interactions between the peripheral metabolism and brain function from a developmental perspective can contribute to prevention and diagnosis programs, as well as early interventions for vulnerable populations.
Identifiants
pubmed: 34635400
pii: S1043-2760(21)00209-5
doi: 10.1016/j.tem.2021.09.003
pii:
doi:
Substances chimiques
Glucocorticoids
0
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1031-1043Subventions
Organisme : CIHR
ID : PJT-166066
Pays : Canada
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.