Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Journal
Pancreas
ISSN: 1536-4828
Titre abrégé: Pancreas
Pays: United States
ID NLM: 8608542
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
22
3
2022
Statut:
ppublish
Résumé
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.
Identifiants
pubmed: 34643606
doi: 10.1097/MPA.0000000000001899
pii: 00006676-202108000-00002
pmc: PMC10273134
mid: NIHMS1881186
doi:
Types de publication
Congress
Langues
eng
Sous-ensembles de citation
IM
Pagination
906-915Subventions
Organisme : NIDDK NIH HHS
ID : K01 DK120737
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK054759
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK122293
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
A.U. is a member of the American Board of Pediatrics, Subboard of Pediatric Gastroenterology; a member of the American Pancreatic Association Governing Board; an associate editor of the Pancreatology; and a consultant of the Cystic Fibrosis Foundation. M.D.B. is a consultant/DSMB member of the Insulet and received research support from ViaCyte and Dexcom. C.E.F. is a consultant of Nestle, received research support from AbbVie, and a board member of the National Pancreas Foundation. L.K. received research support from Medtronic, Nevro, Gimer, Neuros, and SPR Therapeutics; a member of the scientific advisory board of Biotronik and Nalu; and a consultant of Avanos, Nevro, and Nalu. The other authors declare no conflict of interest.
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