Metagenomics and chemotherapy-induced nausea: A roadmap for future research.
chemotherapy
metabolome
microbiome
nausea
prevention
symptoms
Journal
Cancer
ISSN: 1097-0142
Titre abrégé: Cancer
Pays: United States
ID NLM: 0374236
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
revised:
06
07
2021
received:
02
04
2021
accepted:
13
08
2021
pubmed:
14
10
2021
medline:
11
3
2022
entrez:
13
10
2021
Statut:
ppublish
Résumé
Uncontrolled chemotherapy-induced nausea and vomiting can reduce patients' quality of life and may result in premature discontinuation of chemotherapy. Although nausea and vomiting are commonly grouped together, research has shown that antiemetics are clinically effective against chemotherapy-induced vomiting (CIV) but less so against chemotherapy-induced nausea (CIN). Nausea remains a problem for up to 68% of patients who are prescribed guideline-consistent antiemetics. Despite the high prevalence of CIN, relatively little is known regarding its etiology independent of CIV. This review summarizes a metagenomics approach to the study and treatment of CIN with the goal of encouraging future research. Metagenomics focuses on genetic risk factors and encompasses both human (ie, host) and gut microbial genetic variation. Little work to date has focused on metagenomics as a putative biological mechanism of CIN. Metagenomics has the potential to be a powerful tool in advancing scientific understanding of CIN by identifying new biological pathways and intervention targets. The investigation of metagenomics in the context of well-established demographic, clinical, and patient-reported risk factors may help to identify patients at risk and facilitate the prevention and management of CIN.
Identifiants
pubmed: 34643945
doi: 10.1002/cncr.33892
pmc: PMC8776572
mid: NIHMS1734724
doi:
Substances chimiques
Antiemetics
0
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
461-470Subventions
Organisme : NCI NIH HHS
ID : R01 CA219389
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA206110
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR018762
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA090314
Pays : United States
Informations de copyright
© 2021 American Cancer Society.
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