Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
25 01 2022
25 01 2022
Historique:
received:
28
04
2021
accepted:
16
09
2021
pubmed:
14
10
2021
medline:
12
4
2022
entrez:
13
10
2021
Statut:
ppublish
Résumé
We observed high rates of bloodstream infections (BSIs) following fecal microbiota transplantation (FMT) for graft-versus-host-disease (33 events in 22 patients). To trace the BSIs' origin, we applied a metagenomic bioinformatic pipeline screening donor and recipient stool samples for bacteremia-causing strains in 13 cases. Offending strains were not detected in FMT donations. Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii could be detected in stool samples before emerging in the blood. In this largest report of BSIs post-FMT, we present an approach that may be applicable for evaluating BSI origin following microbiota-based interventions. Our findings support FMT safety in immunocompromised patients but do not rule out FMT as an inducer of bacterial translocation.
Identifiants
pubmed: 34644375
pii: 477278
doi: 10.1182/bloodadvances.2021005110
pmc: PMC8791595
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
568-573Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
Références
Blood Adv. 2020 May 12;4(9):1824-1832
pubmed: 32353108
Biol Blood Marrow Transplant. 2019 Aug;25(8):1689-1694
pubmed: 30965140
Microorganisms. 2020 Oct 15;8(10):
pubmed: 33076307
Blood. 2020 Jul 23;136(4):401-409
pubmed: 32526029
Haematologica. 2017 May;102(5):e210-e213
pubmed: 28154090
Genome Res. 2017 Apr;27(4):626-638
pubmed: 28167665
Blood Adv. 2018 Nov 27;2(22):3097-3101
pubmed: 30446486
N Engl J Med. 2019 Nov 21;381(21):2043-2050
pubmed: 31665575
Sci Transl Med. 2020 Jul 1;12(550):
pubmed: 32611682
Transpl Infect Dis. 2020 Feb;22(1):e13217
pubmed: 31769584
Front Immunol. 2018 Sep 25;9:2195
pubmed: 30319644
Bone Marrow Transplant. 2014 Feb;49(2):168-73
pubmed: 23892326
Nature. 2020 Dec;588(7837):303-307
pubmed: 33239790
N Engl J Med. 2017 Nov 30;377(22):2167-2179
pubmed: 29171820
Blood. 2016 Oct 20;128(16):2083-2088
pubmed: 27461930
Cell. 2018 Sep 6;174(6):1388-1405.e21
pubmed: 30193112
Clin Infect Dis. 2012 Oct;55(7):905-14
pubmed: 22718773
Immunity. 2012 Aug 24;37(2):339-50
pubmed: 22921121
PLoS Pathog. 2017 Aug 10;13(8):e1006369
pubmed: 28796836
Sci Transl Med. 2020 Aug 12;12(556):
pubmed: 32801142
Biol Blood Marrow Transplant. 2015 Apr;21(4):761-7
pubmed: 25585275
Nat Immunol. 2016 May;17(5):505-513
pubmed: 26998764