A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development.

Animals Base Sequence Blastocyst / metabolism Cell Proliferation Conserved Sequence Embryonic Development / genetics Evolution, Molecular Female Gene Expression Regulation, Developmental Human Embryonic Stem Cells / metabolism Humans Mammals / genetics Mice, Inbred C57BL Mice, Knockout Models, Biological Promoter Regions, Genetic Protein Isoforms / metabolism Protein Kinases / metabolism Retroelements / genetics Tumor Suppressor Proteins / metabolism
Cdk2 Cdk2ap1 cell proliferation implantation mammals mouse preimplantation embryos promoters retrotransposons transposons

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
28 10 2021
Historique:
received: 23 03 2021
revised: 26 07 2021
accepted: 14 09 2021
pubmed: 14 10 2021
medline: 7 1 2022
entrez: 13 10 2021
Statut: ppublish

Résumé

Retrotransposons mediate gene regulation in important developmental and pathological processes. Here, we characterized the transient retrotransposon induction during preimplantation development of eight mammals. Induced retrotransposons exhibit similar preimplantation profiles across species, conferring gene regulatory activities, particularly through long terminal repeat (LTR) retrotransposon promoters. A mouse-specific MT2B2 retrotransposon promoter generates an N-terminally truncated Cdk2ap1

Identifiants

DOI: 10.1016/j.cell.2021.09.021 PMID: 34644528 PMC: PMC8787082
pubmed: 34644528
pii: S0092-8674(21)01104-1
doi: 10.1016/j.cell.2021.09.021
pmc: PMC8787082
mid: NIHMS1756571
pii:
doi:

Substances chimiques

Protein Isoforms 0
Retroelements 0
Tumor Suppressor Proteins 0
Protein Kinases EC 2.7.-
Cdk2ap1 protein, mouse EC 2.7.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5541-5558.e22

Subventions

Organisme : NIH HHS
ID : R21 OD027053
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS099761
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG010972
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120287
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA180996
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA200060
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096068
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD096108
Pays : United States
Organisme : NIDA NIH HHS
ID : R25 DA027995
Pays : United States
Organisme : NIEHS NIH HHS
ID : U24 ES026699
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA139067
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009391
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG012070
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG007175
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114414
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Andrew J Modzelewski (AJ)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Wanqing Shao (W)

Department of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

Jingqi Chen (J)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Angus Lee (A)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Xin Qi (X)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Mackenzie Noon (M)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Kristy Tjokro (K)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Gabriele Sales (G)

Department of Biology, University of Padova, Padova 35122, Italy.

Anne Biton (A)

Department of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA; Bioinformatics and Biostatistics, Department of Computational Biology, USR 3756 CNRS, Institut Pasteur, Paris 75015, France.

Aparna Anand (A)

Department of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

Terence P Speed (TP)

Bioinformatics Division, WEHI, Parkville, VIC 3052, Australia.

Zhenyu Xuan (Z)

Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.

Ting Wang (T)

Department of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: twang@wustl.edu.

Davide Risso (D)

Department of Statistical Sciences, University of Padova, Padova 35122, Italy. Electronic address: davide.risso@unipd.it.

Lin He (L)

Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: lhe@berkeley.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Blastocyste › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › A mouse-specific retrotransposon drives a...
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questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires humaines › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A mouse-specific retrotransposon drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › A mouse-specific retrotransposon drives a...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A mouse-specific retrotransposon drives a...
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questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Rétroéléments › A mouse-specific retrotransposon drives a...
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