PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8
Adolescent
Adult
Animals
Apoptosis
CD8-Positive T-Lymphocytes
/ enzymology
Case-Control Studies
Child
Chromatin
/ genetics
Chromatin Assembly and Disassembly
Class I Phosphatidylinositol 3-Kinases
/ genetics
Disease Models, Animal
Enzyme Activation
Fas Ligand Protein
/ genetics
Female
HEK293 Cells
Humans
Immunologic Memory
Male
Mice, Inbred C57BL
Mice, Knockout
Primary Immunodeficiency Diseases
/ enzymology
Signal Transduction
Transcription, Genetic
Virus Diseases
/ enzymology
CD8 T cell memory
IL-2
Myc
Phosphatidylinositide 3 Kinase delta (PI3Kδ)
TCF1
apoptosis
effector T cells
long-lived effector cells (LLEC)
mTOR
metabolism
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
12 10 2021
12 10 2021
Historique:
received:
18
10
2020
revised:
15
07
2021
accepted:
16
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
19
2
2022
Statut:
ppublish
Résumé
Patients with activated phosphatidylinositol 3-kinase delta (PI3Kδ) syndrome (APDS) present with sinopulmonary infections, lymphadenopathy, and cytomegalvirus (CMV) and/or Epstein-Barr virus (EBV) viremia, yet why patients fail to clear certain chronic viral infections remains incompletely understood. Using patient samples and a mouse model (Pik3cd
Identifiants
pubmed: 34644563
pii: S2211-1247(21)01264-X
doi: 10.1016/j.celrep.2021.109804
pmc: PMC8582080
mid: NIHMS1747909
pii:
doi:
Substances chimiques
Chromatin
0
FASLG protein, human
0
Fas Ligand Protein
0
Fasl protein, mouse
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CD protein, human
EC 2.7.1.137
Pik3cd protein, mouse
EC 2.7.1.137
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
109804Subventions
Organisme : Intramural NIH HHS
ID : ZIA AI001240
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests S.P. is an employee of AstraZeneca and may own stock or stock options. J.G.-R. is an employee of TCR2. The remaining authors declare no competing interests.
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