Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
AHR
Glioblastoma
MALDI MSI
mass spectrometry
tryptophan
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
03
2021
accepted:
06
08
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.
Identifiants
pubmed: 34646367
doi: 10.7150/thno.60679
pii: thnov11p9217
pmc: PMC8490504
doi:
Substances chimiques
Receptors, Aryl Hydrocarbon
0
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9217-9233Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: A.S., S.T. and C.A.O. are listed as inventors on WO/2020/201825, C.A.O., M.P. and W.W. are listed as inventors on WO/2013/034685, S.K., M.P., P.S.K., I.P. and C.A.O. are listed as inventors on WO/2017/072368. S.K., V.F., S.J., K.K., S.Se., P.S.K. and I.P. have been employed or are employed by Proteome Sciences. W.W. receives trial funding from Apogenix, Boehringer Ingelheim, Pfizer and Roche to the institution. He serves on advisory boards for Agios, Bayer, MSD, Novartis, Roche with compensation paid to the institution. The authors not listed above declare that they have no competing interests.
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