Liprins in oncogenic signaling and cancer cell adhesion.
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
07
07
2021
accepted:
28
09
2021
revised:
21
09
2021
pubmed:
17
10
2021
medline:
31
12
2021
entrez:
16
10
2021
Statut:
ppublish
Résumé
Liprins are a multifunctional family of scaffold proteins, identified by their involvement in several important neuronal functions related to signaling and organization of synaptic structures. More recently, the knowledge on the liprin family has expanded from neuronal functions to processes relevant to cancer progression, including cell adhesion, cell motility, cancer cell invasion, and signaling. These proteins consist of regions, which by prediction are intrinsically disordered, and may be involved in the assembly of supramolecular structures relevant for their functions. This review summarizes the current understanding of the functions of liprins in different cellular processes, with special emphasis on liprins in tumor progression. The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance.
Identifiants
pubmed: 34654889
doi: 10.1038/s41388-021-02048-1
pii: 10.1038/s41388-021-02048-1
pmc: PMC8602034
doi:
Substances chimiques
Biomarkers, Tumor
0
Nuclear Matrix-Associated Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6406-6416Informations de copyright
© 2021. The Author(s).
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