CAD-based hardware attenuation correction in PET/MRI: First methodical investigations and clinical application of a 16-channel RF breast coil.
CAD-based AC
PET/MR breast cancer imaging
attenuation correction (AC)
computer-aided design (CAD)
improved hardware AC
quantitative PET/MR
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
01
10
2021
received:
09
07
2021
accepted:
02
10
2021
pubmed:
17
10
2021
medline:
18
11
2021
entrez:
16
10
2021
Statut:
ppublish
Résumé
Aim of this study was to evaluate the use of computer-aided design (CAD) models for attenuation correction (AC) of hardware components in positron emission tomography/magnetic resonance (PET/MR) imaging. The technical feasibility and quantitative impact of CAD-AC compared to computer tomography (CT)-based AC (reference) was investigated on a modular phantom consisting of 19 different material samples (plastics and metals arranged around a cylindrical emission phantom) typically used in phantoms, patient tables, and radiofrequency (RF) coils in PET/MR. The clinical applicability of the CAD-AC method was then evaluated on a 16-channel RF breast coil in a PET/MR patient study. The RF breast coil in this study was specifically designed PET compatible. Using this RF breast coil, the impact on clinical PET/MR breast imaging was systematically evaluated in breast phantom measurements and, furthermore, in n = 10 PET/MR patients with breast cancer. PET data were reconstructed three times: (1) no AC (NAC), (2) established CT-AC, and (3) CAD-AC. For both phantom measurements, a scan without attenuating hardware components (material probes or RF breast coil) was acquired serving as reference. Relative differences in PET data were calculated for all experiments. In all phantom and patient measurements, significant gains in PET signal compared to NAC data were measurable with CT and CAD-AC. In initial phantom experiments, mean relative differences of -0.2% for CT-AC and 0.2% for CAD-AC were calculated compared to reference measurements without the material probes. The application to a RF breast coil depicts that CAD-AC results in significant gains compared to NAC data (10%) and a slight underestimation in PET signal of -1.3% in comparison to the no-coil reference measurement. In the patient study, a total of 15 congruent lesions in all 10 patients with a mean relative difference of 14% (CT and CAD-AC) in standardized uptake value compared to NAC data could be detected. To ensure best possible PET image quality and accurate PET quantification in PET/MR imaging, the AC of hardware components such as phantoms and RF coils is important. In initial phantom experiments and in clinical application to an RF breast coil, it was found that CAD-based AC results in significant gains in PET signal compared to NAC data and provides comparably good results to the established method of CT-based AC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6696-6709Informations de copyright
© 2021 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
Références
Tellmann L, Quick HH, Bockisch A, et al. The effect of MR surface coils on PET quantification in whole-body PET/MR: results from a pseudo-PET/MR phantom study. Med Phys. 2011;38:2795-2805.
MacDonald LR, Kohlmyer S, Liu C, et al. Effects of MR surface coils on PET quantification. Med Phys. 2011;38:2948-2956.
Delso G, Martinez-Moller A, Bundschuh RA, et al. Evaluation of the attenuation properties of MR equipment for its use in a whole-body PET/MR scanner. Phys Med Biol. 2010;55:4361-4374.
Aklan B, Paulus DH, Wenkel E, et al. Toward simultaneous PET/MR breast imaging: systematic evaluation and integration of a radiofrequency breast coil. Med Phys. 2013;40:1-11.
Oehmigen M, Lindemann ME, Lanz T, et al. Integrated PET/MR breast cancer imaging: attenuation correction and implementation of a 16-channel RF coil. Med Phys. 2016;43(8):4808-4820.
Paulus DH, Braun H, Aklan B, et al. Simultaneous PET/MR imaging: MR-based attenuation correction of local radiofrequency surface coils. Med Phys. 2012; 9(7):4306-4315.
Quick HH. Integrated PET/MR. J Magn Reson Imaging. 2014;39:243-258.
Catana C, v d Kouwe A, Benner T, et al. Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med. 2010;51(9):1431-1438.
Hofmann M, Pichler BJ, Schölkopf B, Beyer T. Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur J Nucl Med Mol Imaging. 2009;36:93-104.
Eldib M, Bini J, Faul DD, et al. Attenuation correction for MR coils in combined PET/MR imaging: a review. PET Clin. 2016;11:151-160.
Bailey DL. Transmission scanning in emission tomography. Eur J Nucl Med. 1998;25:774-787.
Carney J, Townsend D, Rappoport V, Bendriem B. Method for transforming CT images for attenuation correction in PET/CT imaging. Med Phys. 2006;33:976-983.
Zaidi H, Ojha N, Morich M, et al. Design and performance evaluation of a whole-body ingenuity TF PET-MRI system. Phys Med Biol. 2011;56:3091-3106.
Paulus DH, Quick HH. Hybrid positron emission tomography/magnetic resonance imaging: challenges, methods, and state of the art of hardware component attenuation correction. Invest Radiol. 2016;51(10):624-634.
Kinahan PE, Townsend DW, Beyer T, Sashin T. Attenuation correction for a combined 3D PET/CT scanner. Med Phys. 1998;25:2046-2053.
Oehmigen M, Lindemann ME, Tellmann L, et al. Improving the CT (140 kVp) to PET (511 keV) conversion in PET/MR hardware component attenuation correction. Med Phys. 2020;47(5):2116-2127.
Paulus DH, Tellmann L, Quick HH. Towards improved hardware component attenuation correction in PET/MR hybrid imaging. Phys Med Biol. 2013;58:8021-8040.
Kamel EM, Burger C, Buck A, et al. Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner. Eur Radiol. 2003;13:724-728.
Goerres GW, Ziegler SI, Burger C, et al. Artifacts at PET and PET/CT caused by metallic hip prosthetic material. Radiology. 2003;226:577-584.
Wei S, Wang Z & Wang H et al. Design and Implementation of MRI RF Coil based on 3D Printing. 2015 IEEE MTT-S 2015 International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO).
Sander CY, Keil B, Chonde DB, et al. A 31-channel MR brain array coil compatible with positron emission tomography. Magn Reson Med. 2015;73:2363-2375.
Eldib M, Faul D, Ladebeck R, et al. A method for estimating the attenuation correction for the MR hardware of an MR/PET scanner. J Nucl Med Meeting Abstracts. 2012;1(53):371.
Adam & A Mesh voxelization. https://www.mathworks.com/matlabcentral/fileexchange/27390-mesh-voxelisation, Accessed July 22, 2020
Dregely I, Lanz T, Metz S, et al. A 16-channel MR coil for simultaneous PET/MR imaging in breast cancer. Eur Radiol. 2015;25:1154-1161.
Oehmigen M, Lindemann ME, Gratz M, et al. Impact of improved attenuation correction featuring a bone atlas and truncation correction on PET quantification in whole-body PET/MR. Eur J Nucl Med Mol Imaging. 2017;45(4):642-653.
Watson CC. New, faster, image-based scatter correction for 3-D PET. IEEE Trans Nucl Sci. 2000;47:1587-1594.
Paulus DH, Oehmigen M, Grüneisen J, et al. Whole-body hybrid imaging concept for the integration of PET/MR into radiation therapy treatment planning. Phys Med Biol. 2016;61(9):3504-3520.
Sander CY, Keil B, Chonde DB, et al. A 31-channel MR brain array coil compatible with positron emission tomography. Magn Reson Med. 2015;73:2363-2375.
Oehmigen M, Lindemann ME, Gratz M, et al. A dual-tuned 13C/1H head coil for PET/MR hybrid neuroimaging: development, attenuation correction, and first evaluation. Med Phys. 2018;45(11):4877-4887.
Kirchner J, Grueneisen J, Martin O, et al. Local and whole-body staging in patients with primary breast cancer:a comparison of one-step to two-step staging utilizing 18F-FDG-PET/MRI. Eur J Nucl Med Mol Imaging. 2018;45:2328-2337.
Grueneisen J, Sawicki LM, Wetter A. Evaluation of PET and MR datasets in integrated 18F-FDG PET/MRI: a comparison of different MR sequences for whole-body restaging of breast cancer patients. Eur J Radiol. 2017;89:14-19.
Sawicki LM, Grueneisen J, Schaarschmidt BM, et al. Evaluation of 18F-FDG PET/MRI, 18F-FDG PET/CT, MRI, and CT in whole-body staging of recurrent breast cancer. Eur J Radiol. 2016;85(2):459-465.