Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia.

Bone Density Child Glucocorticoids / adverse effects Humans Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy Quality of Life Survivors
Acute lymphoblastic Bone density Child Glucocorticoids Leukemia Quality of life

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 02 04 2020
revised: 05 08 2021
accepted: 08 09 2021
pubmed: 17 10 2021
medline: 15 12 2021
entrez: 16 10 2021
Statut: ppublish

Résumé

Glucocorticoids (GCs) are widely used in the treatment of childhood acute lymphoblastic leukemia (ALL), but their long-term use is also associated with bone-related morbidities. Among others, growth deficit, decreased bone mineral density (BMD) and increased fracture rate are well-documented and severely impact quality of life. Unfortunately, no efficient treatment for the management of bone health impairment in patients and survivors is currently available. The overall goal of this review is to discuss the existing data on how GCs impair bone health in pediatric ALL and attempts made to minimize these side effects.

Identifiants

DOI: 10.1016/j.critrevonc.2021.103492 PMID: 34655742
pubmed: 34655742
pii: S1040-8428(21)00279-1
doi: 10.1016/j.critrevonc.2021.103492
pii:
doi:

Substances chimiques

Glucocorticoids 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103492

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Lilly Velentza (L)

Division of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: lilly.velentza@ki.se.

Farasat Zaman (F)

Division of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Lars Sävendahl (L)

Division of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Densité osseuse › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Bone health in glucocorticoid-treated...
questionsmedicales.fr › Personnes › Survivants › Bone health in glucocorticoid-treated...