Regional age-related atrophy after screening for preclinical alzheimer disease.
Magnetic Resonance Imaging (MRI)
Normal Aging
Preclinical Alzheimer disease
Volumetrics
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
01
04
2021
revised:
15
07
2021
accepted:
07
09
2021
pubmed:
17
10
2021
medline:
19
2
2022
entrez:
16
10
2021
Statut:
ppublish
Résumé
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched.
Identifiants
pubmed: 34655980
pii: S0197-4580(21)00291-8
doi: 10.1016/j.neurobiolaging.2021.09.010
pmc: PMC9009406
mid: NIHMS1793325
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-51Subventions
Organisme : NIA NIH HHS
ID : K01 AG053474
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Organisme : NIH HHS
ID : S10 OD025214
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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