Prevalence of diabetes in people with intellectual disabilities and age- and gender-matched controls: A meta-analysis.
anxiety
depression
hyperglycaemia
hypertension
intellectual disability
Journal
Journal of applied research in intellectual disabilities : JARID
ISSN: 1468-3148
Titre abrégé: J Appl Res Intellect Disabil
Pays: England
ID NLM: 9613616
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
15
07
2021
received:
10
05
2021
accepted:
23
09
2021
pubmed:
19
10
2021
medline:
19
2
2022
entrez:
18
10
2021
Statut:
ppublish
Résumé
This meta-analysis aims to: (i) describe the pooled prevalence of diabetes in people with intellectual disabilities, (ii) investigate the association with demographic, clinical and treatment-related factors and (iii) compare the prevalence versus age- and gender-matched general population controls. Pubmed, Embase and CINAHL were searched until 01 May 2021. Random effects meta-analysis and an odds ratio analysis were conducted to compare rates with controls. The trim- and fill-adjusted pooled diabetes prevalence amongst 55,548 individuals with intellectual disabilities (N studies = 33) was 8.5% (95% CI = 7.2%-10.0%). The trim- and fill-adjusted odds for diabetes was 2.46 times higher (95% CI = 1.89-3.21) (n = 42,684) versus controls (n = 4,177,550). Older age (R Our findings demonstrate that people with intellectual disabilities are at an increased risk of diabetes, and therefore routine screening and multidisciplinary management of diabetes is needed.
Sections du résumé
BACKGROUND
BACKGROUND
This meta-analysis aims to: (i) describe the pooled prevalence of diabetes in people with intellectual disabilities, (ii) investigate the association with demographic, clinical and treatment-related factors and (iii) compare the prevalence versus age- and gender-matched general population controls.
METHODS
METHODS
Pubmed, Embase and CINAHL were searched until 01 May 2021. Random effects meta-analysis and an odds ratio analysis were conducted to compare rates with controls.
RESULTS
RESULTS
The trim- and fill-adjusted pooled diabetes prevalence amongst 55,548 individuals with intellectual disabilities (N studies = 33) was 8.5% (95% CI = 7.2%-10.0%). The trim- and fill-adjusted odds for diabetes was 2.46 times higher (95% CI = 1.89-3.21) (n = 42,684) versus controls (n = 4,177,550). Older age (R
CONCLUSIONS
CONCLUSIONS
Our findings demonstrate that people with intellectual disabilities are at an increased risk of diabetes, and therefore routine screening and multidisciplinary management of diabetes is needed.
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-311Subventions
Organisme : UK Research and Innovation Future Leaders Fellowship
ID : MR/T021780/1
Organisme : NIHR Biomedical Research Centre at South London
Organisme : Clinical Lectureship
ID : ICA-CL-2017-03-001
Organisme : Health Education England (HEE)
Organisme : National Institute for Health Research (NIHR)
Organisme : Guys and St Thomas Charity (GSTT)
Organisme : Medical Research Council
ID : MR/T021780/1
Pays : United Kingdom
Organisme : University of Manchester Presidential Fellowship
ID : P123958
Organisme : South London Maudsley NHS Foundation Trust
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Ali, A., Scior, K., Ratti, V., Strydom, A., King, M., & Hassiotis, A. (2013). Discrimination and other barriers to accessing health care: Perspectives of patients with mild and moderate intellectual disability and their carers. PLoS One, 8(8), e70855.
Balogh, R., Lake, J., Lin, E., Wilton, A., & Lunsky, Y. (2015). Disparities in diabetes prevalence and preventable hospitalizations in people with intellectual and developmental disability: A population-based study. Diabetic Medicine, 32(2), 235-242.
Basheer, R., Jalal, M. J., & Gomez, R. (2016). An unusual case of adolescent type 2 diabetes mellitus: Prader-Willi syndrome. Journal of Family Medicine and Primary Care, 5(1), 181-183.
Begg, C. B., & Mazumdar, M. (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-1101.
Brown, M., Taggart, L., Karatzias, T., Truesdale, M., Walley, R., Northway, R., Macrae, S., Carey, M., & Davies, M. (2017). Improving diabetes care for people with intellectual disabilities: A qualitative study exploring the perceptions and experiences of professionals in diabetes and intellectual disability services. Journal of Intellectual Disability Research, 61(5), 435-449.
Bryant, L., Russell, A., Walwyn, R., Farrin, A., Wright-Hughes, A., Graham, E., Nagi, D., Stansfield, A., Birtwistle, J., Meer, S., Ajjan, R. A., & House, A. O. (2018). Characterizing adults with type 2 diabetes mellitus and intellectual disability: Outcomes of a case-finding study. Diabetic Medicine, 35(3), 352-359.
Cardol, M., Rijken, M., & van Schrojenstein Lantman-de Valk, H. (2012). People with mild to moderate intellectual disability talking about their diabetes and how they manage. Journal of Intellectual Disability Research, 56(4), 351-360.
Chalk, T., Dunkley, A., Gray, L., Spong, R., Gangadharan, S., Davies, M., & Khunti, K. (2016). Rates of type 2 diabetes, cardiovascular disease and associated risk factors in people with intellectual disability populations: Systematic review and meta-analysis: P129. Diabetic Medicine, 33, 73-74.
Coppus, A. (2013). People with intellectual disability: What do we know about adulthood and life expectancy? Developmental Disabilities Research Reviews, 18(1), 6-16.
Crino, A., & Grugni, G. (2020). Update on diabetes mellitus and glucose metabolism alterations in Prader-Willi syndrome. Current Diabetes Reports, 20, 7.
De Boer, I. H., Bangalore, S., Benetos, A., Davis, A. M., Michos, E. D., Muntner, P., Rossing, P., Zoungas, S., & Bakris, G. (2017). Diabetes and hypertension: A position statement by the American Diabetes Association. Diabetes Care, 40(9), 1273-1284.
De Winter, C., Hermans, H., Evenhuis, H., & Echteld, M. (2015). Associations of symptoms of anxiety and depression with diabetes and cardiovascular risk factors in older people with intellectual disability. Journal of Intellectual Disability Research, 59(2), 176-185.
DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7(3), 177-188.
Diaz, K. (2020). Leisure-time physical activity and all-cause mortality among adults with intellectual disability: The National Health Interview Survey. Journal of Intellectual Disability Research, 64(2), 180-184.
Draheim, C. C., Williams, D. P., & McCubbin, J. A. (2002). Physical activity, dietary intake, and the insulin resistance syndrome in nondiabetic adults with mental retardation. American Journal on Mental Retardation, 107(5), 361-375.
Duval, S., & Tweedie, R. (2000). Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56(2), 455-463.
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629-634.
Emerging Risk Factors Collaboration, Sarwar, N., Gao, P., Seshasai, S. R., Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D. A., Selvin, E., Stampfer, M., Stehouwer, C. D., Lewington, S., Pennells, L., Thompson, A., Sattar, N., White, I. R., Ray, K. K., & Danesh, J. (2010). Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet (London, England), 375(9733), 2215-2222. https://doi.org/10.1016/S0140-6736(10)60484-9
Emerson, E. (2005). Underweight, obesity and exercise among adults with intellectual disabilities in supported accommodation in northern England. Journal of Intellectual Disability Research, 49(2), 134-143.
Emerson, E. (2011). Health status and health risks of the “hidden majority” of adults with intellectual disability. Intellectual and Developmental Disabilities, 49(3), 155-165.
Emerson, E., Baines, S., Allerton, L., & Welch, V. (2010). Health inequalities & people with learning disabilities in the UK: 2010, improving health and lives. Learning Disabilities Observatory.
Florio, T., & Trollor, J. (2015). Mortality among a cohort of persons with an intellectual disability in New South Wales, Australia. Journal of Applied Research in Intellectual Disabilities, 28(5), 383-393.
Glover, G., Williams, R., Heslop, P., Oyinlola, J., & Grey, J. (2017). Mortality in people with intellectual disabilities in England. Journal of Intellectual Disability Research, 61(1), 62-74.
Hamzaid, N. H., O'Connor, H. T., & Flood, V. M. (2019). Observed dietary intake in adults with intellectual disability living in group homes. Nutrients, 12(1), 37.
Harwell, T. S., Moore, K., Madison, M., Powell-Taylor, D., Lundgren, P., Smilie, J. G., Acton, K. J., Helgerson, S. D., & Gohdes, D. (2001). Comparing self-reported measures of diabetes care with similar measures from a chart audit in a well-defined population. American Journal of Medical Quality, 16(1), 3-8.
Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. BMJ, 327(7414), 557-560.
Hussain, R., Wark, S., Janicki, M. P., Parmenter, T., & Knox, M. (2020). Multimorbidity in older people with intellectual disability. Journal of Applied Research in Intellectual Disabilities, 33(6), 1234-1244.
Kim, J.-Y., & Yi, E.-S. (2018). Analysis of the relationship between physical activity and metabolic syndrome risk factors in adults with intellectual disabilities. Journal of Exercise Rehabilitation, 14(4), 592-597.
MacRae, S., Brown, M., Karatzias, T., Taggart, L., Truesdale-Kennedy, M., Walley, R., Sierka, A., Northway, R., Carey, M., & Davies, M. (2015). Diabetes in people with intellectual disabilities: A systematic review of the literature. Research in Developmental Disabilities, 47, 352-374.
McGuire, B., Daly, P., & Smyth, F. (2007). Lifestyle and health behaviours of adults with an intellectual disability. Journal of Intellectual Disability Research, 51(7), 497-510.
McVilly, K., McGillivray, J., Curtis, A., Lehmann, J., Morrish, L., & Speight, J. (2014). Diabetes in people with an intellectual disability: A systematic review of prevalence, incidence and impact. Diabetic Medicine, 31(8), 897-904.
Munn, Z., Moola, S., Riitano, D., & Lisy, K. (2014). The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. International Journal of Health Policy and Management, 3(3), 123-128.
Muscogiuri, G., Barrea, L., Faggiano, F., Maiorino, M. I., Parrillo, M., Pugliese, G., Ruggeri, R. M., Scarano, E., Savastano, S., Colao, A., & RESTARE. (2021). Obesity in Prader-Willi syndrome: Physiopathological mechanisms, nutritional and pharmacological approaches. Journal of Endocrinological Investigation, 44, 2057-2070. https://doi.org/10.1007/s40618-021-01574-9
Nouwen, A., Winkley, K., Twisk, J., Lloyd, C. E., Peyrot, M., Ismail, K., & Pouwer, F. (2010). Type 2 diabetes mellitus as a risk factor for the onset of depression: A systematic review and meta-analysis. Diabetologia, 53(12), 2480-2486.
O'Leary, L., Cooper, S. A., & Hughes-McCormack, L. (2018). Early death and causes of death of people with intellectual disabilities: A systematic review. Journal of Applied Research in Intellectual Disabilities, 31(3), 325-342.
Oppewal, A., & Hilgenkamp, T. I. (2020). Is fatness or fitness key for survival in older adults with intellectual disabilities? Journal of Applied Research in Intellectual Disabilities, 33(5), 1016-1025.
Pan, A., Wang, Y., Talaei, M., Hu, F. B., & Wu, T. (2015). Relation of active, passive, and quitting smoking with incident type 2 diabetes: A systematic review and meta-analysis. The Lancet Diabetes & Endocrinology, 3(12), 958-967.
Redquest, B., Ahmed, S., Balogh, R., & Lunsky, Y. (2020). Preventing and treating diabetes in Canadian adults with intellectual and developmental disabilities. Canadian Journal of Diabetes, 44(2), 205-210.
Rosenthal, R. (1979). The file drawer problem and tolerance for null results. Psychological Bulletin, 86(3), 638-641.
Schalock, R. L., Borthwick-Duffy, S. A., Bradley, V. J., Buntinx, W. H., Coulter, D. L., Craig, E. M., Reeve, A., Shogren, A., Snell, M. E., Spreat, S., Tasse, M. J., Thompson, J. R., Verdugo-Alonso, M. A., Wehmeyer, M. L., & Yeager, M. H. (2010). Intellectual disability: Definition, classification, and systems of supports. American Association on Intellectual and Developmental Disabilities.
Sheehan, R., Hassiotis, A., Walters, K., Osborn, D., Strydom, A., & Horsfall, L. (2015). Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study. BMJ, 351, h4326.
Smith, K., Deschênes, S. S., & Schmitz, N. (2018). Investigating the longitudinal association between diabetes and anxiety: A systematic review and meta-analysis. Diabetic Medicine, 35(6), 677-693.
Stroup, D. F., Berlin, J. A., Morton, S. C., Olkin, I., Williamson, G. D., Rennie, D., Moher, D., Becker, B. J., Sipe, T. A., & Thacker, S. B. (2000). Meta-analysis of observational studies in epidemiology: A proposal for reporting. JAMA, 283(15), 2008-2012.
Sun, D., Zhou, T., Heianza, Y., Li, X., Fan, M., Fonseca, V. A., & Qi, L. (2019). Type 2 diabetes and hypertension: A study on bidirectional causality. Circulation Research, 124(6), 930-937.
Taggart, L., Coates, V., & Truesdale-Kennedy, M. (2013). Management and quality indicators of diabetes mellitus in people with intellectual disabilities. Journal of Intellectual Disability Research, 57(12), 1152-1163.
Taggart, L., Truesdale, M., Dunkley, A., House, A., & Russell, A. (2018). Health promotion and wellness initiatives targeting chronic disease prevention and management for adults with intellectual and developmental disabilities: Recent advancements in type 2 diabetes. Current Developmental Disorders Reports, 5(3), 132-142.
Taylor, N., Standen, P., Cutajar, P., Fox, D., & Wilson, D. (2004). Smoking prevalence and knowledge of associated risks in adult attenders at day centres for people with learning disabilities. Journal of Intellectual Disability Research, 48(3), 239-244.
Tracy, J., & Hosken, R. (1997). The importance of smoking education and preventative health strategies for people with intellectual disability. Journal of Intellectual Disability Research, 41(5), 416-421.
Tyrer, F., Dunkley, A., Singh, J., Kristunas, C., Khunti, K., Bhaumik, S., Davies, M. J., Yates, T. E., & Gray, L. (2019). Multimorbidity and lifestyle factors among adults with intellectual disabilities: A cross-sectional analysis of a UK cohort. Journal of Intellectual Disability Research, 63(3), 255-265.
Vancampfort, D., Correll, C. U., Galling, B., Probst, M., De Hert, M., Ward, P. B., Rosenbaum, S., Gaughran, F., Lally, J., & Stubbs, B. (2016). Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: A systematic review and large scale meta-analysis. World Psychiatry, 15(2), 166-174.
Vancampfort, D., Mitchell, A. J., De Hert, M., Sienaert, P., Probst, M., Buys, R., & Stubbs, B. (2015). Type 2 diabetes in patients with major depressive disorder: A meta-analysis of prevalence estimates and predictors. Depression and Anxiety, 32(10), 763-773.