Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels.
Age Factors
Animals
Brain Ischemia
/ drug therapy
Cardiopulmonary Resuscitation
/ methods
Female
Heart Arrest
/ drug therapy
Hippocampus
/ drug effects
Male
Mice
Mice, Inbred C57BL
Nerve Net
/ drug effects
Organ Culture Techniques
Peptide Fragments
/ pharmacology
Recovery of Function
/ drug effects
TRPM Cation Channels
/ antagonists & inhibitors
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
04
2021
accepted:
20
09
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
3
3
2022
Statut:
epublish
Résumé
Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death. Restoration of neuronal function after cell death is an alternative approach (neurorestoration). We previously identified transient receptor potential M2 (TRPM2) ion channels as a potential target for acute neuroprotection and delayed neurorestoration in an adult CA/CPR mouse model. Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in juvenile (p20-25) mice was used to investigate the role of ion TRPM2 channels in neuroprotection and ischemia-induced synaptic dysfunction in the developing brain. Our novel TRPM2 inhibitor, tatM2NX, did not confer protection against CA1 pyramidal cell death but attenuated synaptic plasticity (long-term plasticity (LTP)) deficits in both sexes. Further,
Identifiants
pubmed: 34659399
doi: 10.1155/2021/8774663
pmc: PMC8514917
doi:
Substances chimiques
Peptide Fragments
0
TRPM Cation Channels
0
TRPM2 protein, mouse
0
tatM2NX
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8774663Subventions
Organisme : NINDS NIH HHS
ID : K08 NS097586
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092645
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS046072
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105905
Pays : United States
Informations de copyright
Copyright © 2021 Robert M. Dietz et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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