Complementary Transcriptomic and Proteomic Analysis in the Substantia Nigra of Parkinson's Disease.
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
09
2021
revised:
16
09
2021
accepted:
21
09
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Parkinson's disease (PD) is a disease that involves brain damage and is associated with neuroinflammation, mitochondrial damage, and cell aging. However, the pathogenic mechanism of PD is still unknown. Sequencing data and proteomic data can describe the fluctuation of molecular abundance in diseases at the mRNA level and protein level, respectively. In order to explore new targets in the pathogenesis of PD, the study analyzed molecular changes from the database by combining transcriptomic and proteomic analysis. Differentially expressed genes and differentially abundant proteins were summarized and analyzed. Enrichment and cluster analysis emphasized the importance of neurotransmitter release, mitochondrial damage, and vesicle transport. The molecular network revealed a subnetwork of 9 molecules related to SCNA and TH and revealed hub gene with differential expression at both mRNA and protein levels. It found that ACHE and CADPS could be used as new targets in PD, emphasizing that impaired nerve signal transmission and vesicle transport affect the pathogenesis of PD. Our research emphasized that the joint analysis and verification of transcriptomics and proteomics were devoted to understanding the comprehensive views and mechanism of pathogenesis in PD.
Identifiants
pubmed: 34659588
doi: 10.1155/2021/2148820
pmc: PMC8517625
doi:
Substances chimiques
CADPS protein, human
0
Calcium-Binding Proteins
0
GPI-Linked Proteins
0
Proteins
0
RNA, Messenger
0
Vesicular Transport Proteins
0
ACHE protein, human
EC 3.1.1.7
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2148820Informations de copyright
Copyright © 2021 Bao-hua Dong et al.
Déclaration de conflit d'intérêts
The authors have no actual or potential conflicts of interest.
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