Microglia control glutamatergic synapses in the adult mouse hippocampus.
glutamatergic transmission
hippocampus
learning
microglia
neuron-microglia interaction
synapses
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
20
09
2021
received:
21
02
2021
accepted:
27
09
2021
pubmed:
19
10
2021
medline:
11
3
2022
entrez:
18
10
2021
Statut:
ppublish
Résumé
Microglia cells are active players in regulating synaptic development and plasticity in the brain. However, how they influence the normal functioning of synapses is largely unknown. In this study, we characterized the effects of pharmacological microglia depletion, achieved by administration of PLX5622, on hippocampal CA3-CA1 synapses of adult wild type mice. Following microglial depletion, we observed a reduction of spontaneous and evoked glutamatergic activity associated with a decrease of dendritic spine density. We also observed the appearance of immature synaptic features and higher levels of plasticity. Microglia depleted mice showed a deficit in the acquisition of the Novel Object Recognition task. These events were accompanied by hippocampal astrogliosis, although in the absence ofneuroinflammatory condition. PLX-induced synaptic changes were absent in Cx3cr1
Identifiants
pubmed: 34661306
doi: 10.1002/glia.24101
pmc: PMC9297980
doi:
Substances chimiques
Excitatory Amino Acid Agents
0
Organic Chemicals
0
PLX5622
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-195Informations de copyright
© 2021 The Authors. GLIA published by Wiley Periodicals LLC.
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