Finger somatotopy is preserved after tetraplegia but deteriorates over time.
functional MRI
hand
human
neuroscience
plasticity
somatotopy
spinal cord injury
tetraplegia
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
received:
19
02
2021
accepted:
18
10
2021
pubmed:
20
10
2021
medline:
27
11
2021
entrez:
19
10
2021
Statut:
epublish
Résumé
Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI.
Identifiants
pubmed: 34665133
doi: 10.7554/eLife.67713
pii: 67713
pmc: PMC8575460
doi:
pii:
Banques de données
ClinicalTrials.gov
['NCT03772548']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Kikkert et al.
Déclaration de conflit d'intérêts
SK, DP, MV, PF, NW No competing interests declared
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