Upper Respiratory Tract Microbiome of Australian Aboriginal and Torres Strait Islander Children in Ear and Nose Health and Disease.
Australia
/ epidemiology
Bacteria
/ classification
Child
Child, Preschool
Ear
/ microbiology
Female
Health Status
Humans
Male
Microbiota
/ genetics
Nasal Cavity
/ microbiology
Nasal Mucosa
/ microbiology
Nasopharynx
/ microbiology
Native Hawaiian or Other Pacific Islander
/ statistics & numerical data
Otitis Media
/ epidemiology
Persistent Infection
/ microbiology
RNA, Ribosomal, 16S
/ genetics
Respiratory System
/ microbiology
16S rRNA
Aboriginal and Torres Strait Islander
Corynebacterium
Dolosigranulum
Indigenous
Nose
Ornithobacterium
ecology
microbiome
otitis media
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 10 2021
31 10 2021
Historique:
pubmed:
21
10
2021
medline:
2
2
2022
entrez:
20
10
2021
Statut:
ppublish
Résumé
The objective of this study was to examine the nasal microbiota in relation to otitis media (OM) status and nose health in Indigenous Australian children. Children 2 to 7 years of age were recruited from two northern Australian (Queensland) communities. Clinical histories were obtained through parent interviews and reviews of the medical records. Nasal cavity swab samples were obtained, and the children's ears, nose, and throat were examined. DNA was extracted and analyzed by 16S rRNA amplicon next-generation sequencing of the V3/V4 region, in combination with previously generated culture data. A total of 103 children were recruited (mean age, 4.7 years); 17 (16.8%) were healthy, i.e., normal examination results and no history of OM. The nasal microbiota differed significantly in relation to OM status and nose health. Children with historical OM had greater relative abundance of
Identifiants
pubmed: 34668729
doi: 10.1128/Spectrum.00367-21
pmc: PMC8528113
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0036721Références
Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1548-55
pubmed: 26228497
mSphere. 2020 Sep 9;5(5):
pubmed: 32907957
BMC Pediatr. 2005 Jul 20;5:27
pubmed: 16033643
Med J Aust. 2009 Nov 2;191(S9):S39-43
pubmed: 19883355
PLoS One. 2012;7(4):e36226
pubmed: 22558393
Genome Biol. 2002;3(2):REVIEWS0003
pubmed: 11864374
ISME J. 2017 Dec;11(12):2639-2643
pubmed: 28731476
Am J Respir Crit Care Med. 2017 Dec 15;196(12):1582-1590
pubmed: 28665684
Appl Environ Microbiol. 2012 Sep;78(17):6262-70
pubmed: 22752171
Microbiome. 2018 Nov 5;6(1):199
pubmed: 30396360
BMC Infect Dis. 2014 Jan 09;14:15
pubmed: 24405747
Pediatr Infect Dis J. 2021 Jan;40(1):16-21
pubmed: 33055502
PLoS Pathog. 2016 Aug 04;12(8):e1005812
pubmed: 27490492
Microb Genom. 2019 Feb;5(2):
pubmed: 30720420
Microbiome. 2016 Jul 07;4(1):37
pubmed: 27388563
Am J Respir Crit Care Med. 2014 Dec 1;190(11):1283-92
pubmed: 25329446
J Pediatric Infect Dis Soc. 2021 Apr 30;10(4):468-476
pubmed: 33393596
PLoS Negl Trop Dis. 2017 Oct 2;11(10):e0005975
pubmed: 28968382
Cell Host Microbe. 2018 Sep 12;24(3):341-352.e5
pubmed: 30212648
Microbiome. 2019 Jul 16;7(1):106
pubmed: 31311598
BMC Microbiol. 2018 Feb 20;18(1):13
pubmed: 29458340