Temporal and spatial evolution of various functional neurons during demyelination induced by cuprizone.
Animals
Astrocytes
/ drug effects
Axons
/ drug effects
Cuprizone
/ administration & dosage
Demyelinating Diseases
/ chemically induced
Disease Models, Animal
Glutamic Acid
/ metabolism
Mice
Monoamine Oxidase Inhibitors
/ administration & dosage
Multiple Sclerosis
/ metabolism
Myelin Sheath
/ drug effects
Neurons
/ drug effects
CPZ-induced demyelination
astrocyte
glutamate
glutamate neuron
Journal
Journal of neurophysiology
ISSN: 1522-1598
Titre abrégé: J Neurophysiol
Pays: United States
ID NLM: 0375404
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
pubmed:
21
10
2021
medline:
11
3
2022
entrez:
20
10
2021
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Here we report the temporal and spatial evolution of various functional neurons during demyelination in a cuprizone (CPZ)-induced mouse model. CPZ did not significantly induce the damage of axons and neurons after 2 wk of feeding. However, after 4-6 wk of CPZ feeding, axons and neurons were markedly reduced in the cortex, posterior thalamic nuclear group, and hippocampus. Simultaneously, the expression of TPH
Identifiants
pubmed: 34669500
doi: 10.1152/jn.00224.2021
doi:
Substances chimiques
Monoamine Oxidase Inhibitors
0
Glutamic Acid
3KX376GY7L
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM