Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identifies European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States.
admixture mapping
chronic kidney disease
eGFR
kidney function
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
07
05
2021
accepted:
08
09
2021
pubmed:
22
10
2021
medline:
19
2
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
Admixture mapping is a powerful approach for gene mapping of complex traits that leverages the diverse genetic ancestry in populations with recent admixture, such as Hispanic or Latino individuals in the United States. These individuals have an increased risk of CKD. We performed genome-wide admixture mapping for both CKD and eGFR in a sample of 12,601 participants from the Hispanic Community Health Study/Study of Latinos, with validation in a sample of 8191 Black participants from the Women's Health Initiative (WHI). We also compared the findings with those from a conventional genome-wide association study. Three novel ancestry-of-origin loci were identified on chromosomes 2, 14, and 15 for CKD and eGFR. The chromosome 2 locus comprises two European ancestry regions encompassing the This study provides evidence of shared ancestry-specific genomic regions influencing eGFR in Hispanic or Latino individuals and Black individuals and illustrates the potential for leveraging genetic ancestry in recently admixed populations for the discovery of novel candidate loci for kidney phenotypes.
Sections du résumé
BACKGROUND
Admixture mapping is a powerful approach for gene mapping of complex traits that leverages the diverse genetic ancestry in populations with recent admixture, such as Hispanic or Latino individuals in the United States. These individuals have an increased risk of CKD.
METHODS
We performed genome-wide admixture mapping for both CKD and eGFR in a sample of 12,601 participants from the Hispanic Community Health Study/Study of Latinos, with validation in a sample of 8191 Black participants from the Women's Health Initiative (WHI). We also compared the findings with those from a conventional genome-wide association study.
RESULTS
Three novel ancestry-of-origin loci were identified on chromosomes 2, 14, and 15 for CKD and eGFR. The chromosome 2 locus comprises two European ancestry regions encompassing the
CONCLUSIONS
This study provides evidence of shared ancestry-specific genomic regions influencing eGFR in Hispanic or Latino individuals and Black individuals and illustrates the potential for leveraging genetic ancestry in recently admixed populations for the discovery of novel candidate loci for kidney phenotypes.
Identifiants
pubmed: 34670813
pii: 00001751-202201000-00012
doi: 10.1681/ASN.2021050617
pmc: PMC8763178
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-87Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117445
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065237
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052354
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065233
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD012765
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065235
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201300005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065234
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065236
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL123677
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
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