Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina.
Angina, Stable
/ blood
Biomarkers
/ blood
Cardiomyopathies
/ blood
Cholesterol
/ blood
Cholesterol, HDL
/ blood
Cholesterol, LDL
/ blood
Coronary Angiography
/ methods
Coronary Artery Disease
/ blood
Female
Humans
Hypolipidemic Agents
/ pharmacology
Insulin Resistance
/ physiology
Male
Metabolic Syndrome
/ blood
Middle Aged
Risk Factors
Triglycerides
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 10 2021
20 10 2021
Historique:
received:
06
04
2021
accepted:
05
10
2021
entrez:
21
10
2021
pubmed:
22
10
2021
medline:
28
1
2022
Statut:
epublish
Résumé
We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with stable angina who underwent coronary computed tomography angiography (CTA), were managed clinically and followed for 4.5 ± 0.9 years. The primary composite outcome was all-cause mortality and non-fatal myocardial infarction. At baseline, the proportion of males, patients with metabolic syndrome, diabetes and obstructive CAD increased across TG/HDL-C ratio quartiles, together with markers of insulin resistance, hepatic and adipose tissue dysfunction and myocardial damage, with no difference in total cholesterol or LDL-C. At follow-up, the global CTA risk score (HR 1.06, 95% confidence interval (CI) 1.03-1.09, P = 0.001) and the IV quartile of the TG/HDL-C ratio (HR 2.85, 95% CI 1.30-6.26, P < 0.01) were the only independent predictors of the primary outcome. The TG/HDL-C ratio and the CTA risk score progressed over time despite increased use of lipid-lowering drugs and reduction in LDL-C. In patients with stable angina, high TG and low HDL-C levels are associated with CAD related outcomes independently of LDL-C and treatments.Trial registration. EVINCI study: ClinicalTrials.gov NCT00979199, registered September 17, 2009; SMARTool study: ClinicalTrials.gov NCT04448691, registered June 26, 2020.
Identifiants
pubmed: 34671067
doi: 10.1038/s41598-021-00020-3
pii: 10.1038/s41598-021-00020-3
pmc: PMC8528835
doi:
Substances chimiques
Biomarkers
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Hypolipidemic Agents
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Banques de données
ClinicalTrials.gov
['NCT04448691', 'NCT00979199']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20714Informations de copyright
© 2021. The Author(s).
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