Emerging roles for CNS fibroblasts in health, injury and disease.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
accepted:
31
08
2021
pubmed:
22
10
2021
medline:
26
2
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
Recent transcriptomic, histological and functional studies have begun to shine light on the fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and spinal cord. Although the origins and functions of CNS fibroblasts are still being described, it is clear that they represent a distinct cell population, or populations, that have likely been confused with other cell types on the basis of the expression of overlapping cellular markers. Recent work has revealed that fibroblasts play crucial roles in fibrotic scar formation in the CNS after injury and inflammation, which have also been attributed to other perivascular cell types such as pericytes and vascular smooth muscle cells. In this Review, we describe the current knowledge of the location and identity of CNS perivascular cell types, with a particular focus on CNS fibroblasts, including their origin, subtypes, roles in health and disease, and future areas for study.
Identifiants
pubmed: 34671105
doi: 10.1038/s41583-021-00525-w
pii: 10.1038/s41583-021-00525-w
pmc: PMC8527980
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-34Subventions
Organisme : NINDS NIH HHS
ID : R01 NS091281
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS108651
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS098273
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS098273
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS125875
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103844
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS119615
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007752
Pays : United States
Informations de copyright
© 2021. Springer Nature Limited.
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