The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver.

extra virgin olive oil (EVOO) hepatic stellate (Ito) cell (HSC) inflammation liver fibrosis miRNA oleocanthal oxidative stress

Journal

Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264

Informations de publication

Date de publication:
2021
Historique:
received: 10 06 2021
accepted: 08 09 2021
entrez: 21 10 2021
pubmed: 22 10 2021
medline: 22 10 2021
Statut: epublish

Résumé

Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated the anti-fibrotic and anti-inflammatory effects of the polyphenol oleocanthal (OC) extracted from extra virgin olive oil (EVOO) by an

Identifiants

pubmed: 34671630
doi: 10.3389/fnut.2021.715183
pmc: PMC8521071
doi:

Types de publication

Journal Article

Langues

eng

Pagination

715183

Informations de copyright

Copyright © 2021 Gabbia, Carpi, Sarcognato, Cannella, Colognesi, Scaffidi, Polini, Digiacomo, Esposito Salsano, Manera, Macchia, Nieri, Carrara, Russo, Guido and De Martin.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Nutrients. 2018 May 06;10(5):
pubmed: 29734791
Annu Rev Pathol. 2011;6:425-56
pubmed: 21073339
Biomedicines. 2021 Jun 17;9(6):
pubmed: 34204571
Nucleic Acids Res. 2018 Jan 4;46(D1):D296-D302
pubmed: 29126174
J Nutr Biochem. 2013 Aug;24(8):1513-9
pubmed: 23477728
Nature. 2005 Sep 1;437(7055):45-6
pubmed: 16136122
JGH Open. 2018 May 24;2(4):117-123
pubmed: 30483575
J Gastroenterol Hepatol. 2014 May;29(5):1073-82
pubmed: 24325631
J Clin Invest. 2017 Jan 3;127(1):55-64
pubmed: 28045404
Hepatol Res. 2015 Jul;45(7):794-803
pubmed: 25163538
JHEP Rep. 2020 Apr 18;2(4):100115
pubmed: 32637906
World J Gastroenterol. 2017 Nov 14;23(42):7519-7530
pubmed: 29204052
Nutrients. 2019 Jul 15;11(7):
pubmed: 31311123
Hepatology. 2011 Jan;53(1):209-18
pubmed: 20890893
J Clin Exp Hepatol. 2019 Mar-Apr;9(2):221-232
pubmed: 31024205
J Immunol Methods. 1995 Oct 26;186(2):275-84
pubmed: 7594627
Nutrients. 2019 Oct 29;11(11):
pubmed: 31671785
Life Sci. 2012 Dec 10;91(23-24):1229-35
pubmed: 23044226
Drug Metab Dispos. 2014 Oct;42(10):1617-26
pubmed: 25030308
Life Sci. 2019 Oct 15;235:116817
pubmed: 31476309
Gene Expr. 2015;16(4):155-62
pubmed: 26637395
Am J Transl Res. 2016 Nov 15;8(11):4764-4777
pubmed: 27904678
Gut. 2012 Nov;61(11):1600-9
pubmed: 22267590
Toxicol In Vitro. 2018 Oct;52:243-250
pubmed: 29959992
Arch Med Sci. 2020 Aug 10;16(5):1150-1157
pubmed: 32864004
J Biochem. 2020 Dec 26;168(6):603-609
pubmed: 32653922
J Hepatol. 2019 Jan;70(1):151-171
pubmed: 30266282
Nutr Cancer. 2016 Jul;68(5):873-7
pubmed: 27266366
Adv Drug Deliv Rev. 2018 Apr;129:54-63
pubmed: 29391222
Antioxidants (Basel). 2020 Dec 15;9(12):
pubmed: 33333846
Horm Cancer. 2018 Oct;9(5):295-325
pubmed: 29987748
J Nutr Biochem. 2014 Feb;25(2):186-92
pubmed: 24445043
PLoS One. 2015 Jul 29;10(7):e0129743
pubmed: 26222337
World J Hepatol. 2021 Feb 27;13(2):218-232
pubmed: 33708351
Antioxidants (Basel). 2015 Aug 13;4(3):548-62
pubmed: 26783843
Front Pharmacol. 2020 Sep 23;11:574317
pubmed: 33071785
Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G807-30
pubmed: 25767261
Cells. 2020 Jul 23;9(8):
pubmed: 32717951
Nutrients. 2020 Jul 09;12(7):
pubmed: 32660099
Front Med (Lausanne). 2021 Feb 05;8:627927
pubmed: 33614685
Front Physiol. 2016 Feb 02;7:17
pubmed: 26869935
J Nutr. 2019 Nov 1;149(11):1920-1929
pubmed: 31334554
Eur J Nutr. 2019 Mar;58(2):565-581
pubmed: 29450729
Am J Pathol. 2007 Jun;170(6):1942-53
pubmed: 17525262
Cells. 2019 Oct 11;8(10):
pubmed: 31614673
BMC Complement Altern Med. 2016 Nov 4;16(1):438
pubmed: 27814700
Metabolites. 2020 Oct 02;10(10):
pubmed: 33023123
Pharmaceutics. 2021 Jun 23;13(7):
pubmed: 34201494
Drug Metab Pharmacokinet. 2012;27(6):640-52
pubmed: 22785257
Lab Anim. 2015 Apr;49(1 Suppl):4-11
pubmed: 25835733
Food Funct. 2021 May 11;12(9):3898-3918
pubmed: 33977953
Sci Rep. 2020 Dec 3;10(1):21018
pubmed: 33273492
Appl Immunohistochem Mol Morphol. 2017 Apr;25(4):261-270
pubmed: 26990742
Turk Neurosurg. 2018;28(6):858-865
pubmed: 29204981
World J Gastroenterol. 2020 Oct 7;26(37):5629-5645
pubmed: 33088157
Drug Des Devel Ther. 2019 Aug 01;13:2667-2676
pubmed: 31534314
PLoS One. 2014 May 15;9(5):e97592
pubmed: 24831942
Clin Res Hepatol Gastroenterol. 2019 Oct;43(5):575-584
pubmed: 30857885
Antioxidants (Basel). 2021 May 28;10(6):
pubmed: 34071441
PLoS One. 2018 Sep 25;13(9):e0204336
pubmed: 30252871
J Agric Food Chem. 1999 Jan;47(1):12-8
pubmed: 10563841
Mol Med Rep. 2019 Apr;19(4):3305-3313
pubmed: 30816527
Br J Pharmacol. 2020 Mar;177(6):1316-1330
pubmed: 31270815

Auteurs

Daniela Gabbia (D)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Sara Carpi (S)

Department of Pharmacy, University of Pisa, Pisa, Italy.
NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy.

Samantha Sarcognato (S)

Department of Medicine, University of Padova, Padova, Italy.

Luana Cannella (L)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Martina Colognesi (M)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Michela Scaffidi (M)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Beatrice Polini (B)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Maria Digiacomo (M)

Department of Pharmacy, University of Pisa, Pisa, Italy.
Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

Jasmine Esposito Salsano (J)

Department of Pharmacy, University of Pisa, Pisa, Italy.
Doctoral School in Life Sciences, University of Siena, Siena, Italy.

Clementina Manera (C)

Department of Pharmacy, University of Pisa, Pisa, Italy.
Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

Marco Macchia (M)

Department of Pharmacy, University of Pisa, Pisa, Italy.
Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

Paola Nieri (P)

Department of Pharmacy, University of Pisa, Pisa, Italy.
Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

Maria Carrara (M)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Francesco Paolo Russo (FP)

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Maria Guido (M)

Department of Medicine, University of Padova, Padova, Italy.

Sara De Martin (S)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Classifications MeSH