A score appraising Paleolithic diet and the risk of cardiovascular disease in a Mediterranean prospective cohort.
Cardiovascular risk
Cohort study
Dietary patterns
Mediterranean diet
Paleolithic diet
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
16
04
2021
accepted:
01
10
2021
pubmed:
22
10
2021
medline:
22
2
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
To assess the association between a score appraising adherence to the PaleoDiet and the risk of cardiovascular disease (CVD) in a Mediterranean cohort. We included 18,210 participants from the Seguimiento Universidad de Navarra (SUN) cohort study. The PaleoDiet score comprised six food groups promoted within this diet (fruit, nuts, vegetables, eggs, meat and fish) and five food groups whose consumption is discouraged (cereals and grains, dairy products, legumes, culinary ingredients, and processed/ultra-processed foods). CVD was defined as acute myocardial infarction with or without ST elevation, non-fatal stroke and cardiovascular death. Cox proportional hazards models adjusted for potential confounders were fitted to assess the association between the PaleoDiet score and CVD risk, and the PaleoDiet and MedDiet indices to explore differences between both diets. During 12.2 years of follow-up, 165 incident CVD cases were confirmed. A significant inverse association was found between the PaleoDiet score and CVD (HR Q5 vs. Q1: 0.45, 95% CI 0.27-0.76, P for trend = 0.007). A weaker association that became non-significant was observed when the item for low consumption of ultra-processed foods was removed from the score. Joint analysis of PaleoDiet and MedDiet Trichopoulou scores suggested that the inverse association between PaleoDiet and CVD was mainly present when adherence to the MedDiet was also high (HR for high adherence vs low adherence to both diet scores: 0.22, 95% CI 0.08-0.64). Our findings suggest that the PaleoDiet may have cardiovascular benefits in participants from a Mediterranean country. Avoidance of ultra-processed foods seems to play a key role in this inverse association.
Identifiants
pubmed: 34671828
doi: 10.1007/s00394-021-02696-9
pii: 10.1007/s00394-021-02696-9
pmc: PMC8854325
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
957-971Subventions
Organisme : Instituto de Salud Carlos III
ID : PI10/02658
Organisme : Instituto de Salud Carlos III
ID : PI10/02293
Organisme : Instituto de Salud Carlos III
ID : PI13/00615
Organisme : Instituto de Salud Carlos III
ID : PI14/01668
Organisme : Instituto de Salud Carlos III
ID : PI14/01798
Organisme : Instituto de Salud Carlos III
ID : PI14/01764
Organisme : Instituto de Salud Carlos III
ID : PI17/01795
Organisme : Gobierno de navarra
ID : 45/2011
Organisme : Gobierno de navarra
ID : 122/2014
Organisme : Gobierno de navarra
ID : 41/2016
Informations de copyright
© 2021. The Author(s).
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