PROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteins.

Apoptosis / genetics Chaperonin 60 / blood Child Child, Preschool Endothelial Cells / metabolism Female HSP27 Heat-Shock Proteins / blood HSP40 Heat-Shock Proteins / blood HSP47 Heat-Shock Proteins / blood HSP70 Heat-Shock Proteins / blood HSP72 Heat-Shock Proteins / blood HSP90 Heat-Shock Proteins / blood Heat-Shock Proteins / blood Humans Inflammation / blood Male Oxidative Stress / genetics Renal Insufficiency, Chronic / blood

CKD Chronic kidney disease HSP Heat shock protein Progression

Journal

Cell stress & chaperones

ISSN: 1466-1268

Titre abrégé: Cell Stress Chaperones

Pays: Netherlands

ID NLM: 9610925

Informations de publication

Date de publication:
11 2021

Historique:

received: 24 06 2021

accepted: 23 09 2021

revised: 22 09 2021

pubmed: 22 10 2021

medline: 1 3 2022

entrez: 21 10 2021

Statut: ppublish

Résumé

Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.

Identifiants

DOI: 10.1007/s12192-021-01239-9 PMID: 34671941 PMC: PMC8578260

pubmed: 34671941

doi: 10.1007/s12192-021-01239-9

pii: 10.1007/s12192-021-01239-9

pmc: PMC8578260

doi:

Substances chimiques

Chaperonin 60 0

HSP27 Heat-Shock Proteins 0

HSP40 Heat-Shock Proteins 0

HSP47 Heat-Shock Proteins 0

HSP70 Heat-Shock Proteins 0

HSP72 Heat-Shock Proteins 0

HSP90 Heat-Shock Proteins 0

Heat-Shock Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

973-987

Subventions

Organisme : türkiye bilimsel ve teknolojik araştirma kurumu

ID : 115S365

Informations de copyright

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