Brain Motor Region Diffusion Tensor Imaging in Patients with Catatonic Schizophrenia: A Case-Control Study.
Adult
Anisotropy
Cerebellum
/ diagnostic imaging
Connectome
/ methods
Corpus Callosum
/ diagnostic imaging
Correlation of Data
Diagnostic and Statistical Manual of Mental Disorders
Diffusion Tensor Imaging
/ methods
Female
Humans
Internal Capsule
/ diagnostic imaging
Male
Motor Cortex
/ diagnostic imaging
Psychiatric Status Rating Scales
Schizophrenia, Catatonic
/ diagnosis
Journal
The Israel Medical Association journal : IMAJ
ISSN: 1565-1088
Titre abrégé: Isr Med Assoc J
Pays: Israel
ID NLM: 100930740
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
21
10
2021
pubmed:
22
10
2021
medline:
27
10
2021
Statut:
ppublish
Résumé
Only a small proportion of schizophrenia patients present with catatonic symptoms. Imaging studies suggest that brain motor circuits are involved in the underlying pathology of catatonia. However, data about diffusivity dysregulation of these circuits in catatonic schizophrenia are scarce. To assess the involvement of brain motor circuits in schizophrenia patients with catatonia. Diffusion tensor imaging (DTI) was used to measure white matter signals in selected brain regions linked to motor circuits. Relevant DTI data of seven catatonic schizophrenia patients were compared to those of seven non-catatonic schizophrenia patients, matched for sex, age, and education level. Significantly elevated fractional anisotropy values were found in the splenium of the corpus callosum, the right peduncle of the cerebellum, and the right internal capsule of the schizophrenia patients with catatonia compared to those without catatonia. This finding showed altered diffusivity in selected motor-related brain areas. Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.
Sections du résumé
BACKGROUND
BACKGROUND
Only a small proportion of schizophrenia patients present with catatonic symptoms. Imaging studies suggest that brain motor circuits are involved in the underlying pathology of catatonia. However, data about diffusivity dysregulation of these circuits in catatonic schizophrenia are scarce.
OBJECTIVES
OBJECTIVE
To assess the involvement of brain motor circuits in schizophrenia patients with catatonia.
METHODS
METHODS
Diffusion tensor imaging (DTI) was used to measure white matter signals in selected brain regions linked to motor circuits. Relevant DTI data of seven catatonic schizophrenia patients were compared to those of seven non-catatonic schizophrenia patients, matched for sex, age, and education level.
RESULTS
RESULTS
Significantly elevated fractional anisotropy values were found in the splenium of the corpus callosum, the right peduncle of the cerebellum, and the right internal capsule of the schizophrenia patients with catatonia compared to those without catatonia. This finding showed altered diffusivity in selected motor-related brain areas.
CONCLUSIONS
CONCLUSIONS
Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM