Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography.
Aged
Autoantibodies
/ blood
Biomarkers
/ blood
Coronary Angiography
/ methods
Coronary Artery Disease
/ diagnosis
Endothelium, Vascular
/ immunology
Female
Follow-Up Studies
Humans
Immunologic Tests
/ methods
Israel
/ epidemiology
Male
Prognosis
Protective Factors
Reproducibility of Results
Risk Assessment
/ methods
Journal
The Israel Medical Association journal : IMAJ
ISSN: 1565-1088
Titre abrégé: Isr Med Assoc J
Pays: Israel
ID NLM: 100930740
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
21
10
2021
pubmed:
22
10
2021
medline:
27
10
2021
Statut:
ppublish
Résumé
Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease. To determine the relation between natural AECA levels and prognosis related to coronary artery disease. Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up. Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels (< 1 OD unit, group 2). Both groups did not differ in age, sex, or presence of diabetes. The median follow up was 2293 days (76 months). Patients with high AECA levels were more likely to have normal coronary arteries on angiography (21.6% vs. 16.9%, P = 0.047) and less likely to have calcified lesions (19.0% vs. 26.6%, P = 0.028) and lower prevalence of abnormal renal functions (71.1 mg/dl vs. 66.5 mg/dl, P = 0.033). Patients with higher AECA levels had lower mortality levels (20.1% vs. 27.6%, P = 0.006). A logistic regression model demonstrated independent association between lower AECA levels and the presence of coronary atherosclerosis based on angiogram. After a median of more than 6 years, higher natural AECA levels were associated with less coronary artery disease and lower mortality rates in patients undergoing coronary angiography.
Sections du résumé
BACKGROUND
BACKGROUND
Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease.
OBJECTIVES
OBJECTIVE
To determine the relation between natural AECA levels and prognosis related to coronary artery disease.
METHODS
METHODS
Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up.
RESULTS
RESULTS
Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels (< 1 OD unit, group 2). Both groups did not differ in age, sex, or presence of diabetes. The median follow up was 2293 days (76 months). Patients with high AECA levels were more likely to have normal coronary arteries on angiography (21.6% vs. 16.9%, P = 0.047) and less likely to have calcified lesions (19.0% vs. 26.6%, P = 0.028) and lower prevalence of abnormal renal functions (71.1 mg/dl vs. 66.5 mg/dl, P = 0.033). Patients with higher AECA levels had lower mortality levels (20.1% vs. 27.6%, P = 0.006). A logistic regression model demonstrated independent association between lower AECA levels and the presence of coronary atherosclerosis based on angiogram.
CONCLUSIONS
CONCLUSIONS
After a median of more than 6 years, higher natural AECA levels were associated with less coronary artery disease and lower mortality rates in patients undergoing coronary angiography.
Substances chimiques
Autoantibodies
0
Biomarkers
0
anti-endothelial cell antibody
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM