Adult-onset immunodeficiency due to anti-interferon-gamma autoantibody-associated Sweet syndrome: A distinctive entity.
Sweet syndrome
acute febrile neutrophilic dermatosis
adult-onset immunodeficiency
anti-interferon-γ autoantibody
disseminated non-tuberculous mycobacterial infection
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
revised:
12
09
2021
received:
24
06
2021
accepted:
05
10
2021
pubmed:
23
10
2021
medline:
6
1
2022
entrez:
22
10
2021
Statut:
ppublish
Résumé
Sweet syndrome (SS) has been increasingly reported in patients with adult-onset immunodeficiency (AOID) due to anti-interferon-γ autoantibody who also have concomitant opportunistic infections, especially disseminated non-tuberculous mycobacterial infection (dNTMI). A retrospective study retrieving data from 2011 through 2020 was conducted. We compared clinical characteristics of SS with and without AOID and generated the prediction model and examined the interaction between AOID and dNTMI in the occurrence of SS. Lymphadenopathy, pustular lesions, and leukocytosis are the significant predictors for AOID-associated SS. Adjusted risk differences were 0.58 (95% confidence interval [CI], 0.33-0.83), 0.21 (95% CI, 0.02-0.39), and 0.24 (95% CI, 0.01-0.47), respectively. Based on the analysis of aggregated cross-sectional data, both the overall and the direct effect of AOID increased the prevalence of SS. The indirect effect of AOID on the occurrence of SS might also be mediated through dNTMI or other common opportunistic infections. In addition, there was a trend of positive additive interaction between AOID and dNTMI. Although the test of additive interaction did not reveal statistically significant results, a deviation from additivity of isolated effects might suggest potential causal interaction between AOID and dNTMI. The distinctive clinical syndrome comprising lymphadenopathy, pustular lesions, and leukocytosis in patients with SS should raise the awareness of clinicians to the potential of underlying AOID.
Identifiants
pubmed: 34676591
doi: 10.1111/1346-8138.16202
doi:
Substances chimiques
Autoantibodies
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-141Subventions
Organisme : Faculty of Medicine Research Fund
ID : grant no.109-2563
Informations de copyright
© 2021 Japanese Dermatological Association.
Références
Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349-56.
Corazza M, Lauriola MM, Borghi A, Marzola A, Virgili A. Sweet’s syndrome: a retrospective clinical, histopathological and immunohistochemical analysis of 11 cases. Acta Derm Venereol. 2008;88:601-6.
Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol. 2013;69:557-64.
Rochael MC, Pantaleao L, Vilar EA, Zacaron LH, Spada EQ, Xavier MHSB, et al. Sweet’s syndrome: study of 73 cases, emphasizing histopathological findings. An Bras Dermatol. 2011;86:702-7.
Abbas O, Kibbi AG, Rubeiz N. Sweet’s syndrome: retrospective study of clinical and histologic features of 44 cases from a tertiary care center. Int J Dermatol. 2010;49:1244-9.
Amouri M, Masmoudi A, Ammar M, Boudaya S, Khabir A, Boudawara T, et al. Sweet’s syndrome: a retrospective study of 90 cases from a tertiary care center. Int J Dermatol. 2016;55:1033-9.
Ratzinger G, Burgdorf W, Zelger BG, Zelger B. Acute febrile neutrophilic dermatosis: a histopathologic study of 31 cases with review of literature. Am J Dermatopathol. 2007;29:125-33.
Marcoval J, Martin-Callizo C, Valenti-Medina F, Bonfill-Orti M, Martinez-Molina L. Sweet syndrome: long-term follow-up of 138 patients. Clin Exp Dermatol. 2016;41:741-6.
Chaowattanapanit S, Choonhakarn C, Chetchotisakd P, Sawanyawisuth K, Julanon N. Clinical features and outcomes of Sweet’s syndrome associated with non-tuberculous mycobacterial infection and other associated diseases. J Dermatol. 2016;43:532-6.
Chan JF, Trendell-Smith NJ, Chan JC, Hung I-N, Tang B-F, Cheng V-C, et al. Reactive and infective dermatoses associated with adult-onset immunodeficiency due to anti-interferon-gamma autoantibody: Sweet’s syndrome and beyond. Dermatology. 2013;226:157-66.
Chiewchanvit S. Reactive neutrophilic dermatoses associated with nontuberculous mycobacterial infection in adult onset immunodeficiency syndrome responded well to acitretin: four cases report. J Med Assoc Thai. 2013;96:1609-1616.
Tuchinda C. Sweet’s syndrome: a reaction to non-tuberculous mycobacterial infections. J Med Assoc Thai. 2001;87:567-72.
Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, et al. Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med. 2012;367:725-34.
Jutivorakool K, Sittiwattanawong P, Kantikosum K, Hurst C, Kumtornrut C, Asawanonda P, et al. Skin manifestations in patients with adult-onset immunodeficiency due to anti-interferon-gamma autoantibody: a relationship with systemic infections. Acta Derm Venereol. 2018;98:742-7.
von den Driesch P. Sweet’s syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol. 1994;31:535-56:quiz 557-560.
Browne SK. Anticytokine autoantibody-associated immunodeficiency. Annu Rev Immunol. 2014;32:635-57.
Merkel PA, Lebo T, Knight V. Functional analysis of anti-cytokine autoantibodies using flow cytometry. Front Immunol. 2019;10:1517.
Wongkulab P, Wipasa J, Chaiwarith R, Supparatpinyo K. Autoantibody to interferon-gamma associated with adult-onset immunodeficiency in non-HIV individuals in Northern Thailand. PLoS One. 2013;8:e76371.
Chetchotisakd P, Kiertiburanakul S, Mootsikapun P, Assanasen S, Chaiwarith R, Anunnatsiri S. Disseminated nontuberculous mycobacterial infection in patients who are not infected with HIV in Thailand. Clin Infect Dis. 2007;45:421-7.
Aoki A, Sakagami T, Yoshizawa K, et al. Clinical significance of interferon-gamma neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease. Clin Infect Dis. 2018;66:1239-45.
Nofal A, Abdelmaksoud A, Amer H, et al. Sweet’s syndrome: diagnostic criteria revisited. J Dtsch Dermatol Ges. 2017;15:1081-8.
Su WP, Liu HN. Diagnostic criteria for Sweet’s syndrome. Cutis. 1986;37:167-74.
Rujiwetpongstorn R, Chuamanochan M, Tovanabutra N, Chaiwarith R, Chiewchanvit S. Efficacy of acitretin in the treatment of reactive neutrophilic dermatoses in adult-onset immunodeficiency due to interferon-gamma autoantibody. J Dermatol. 2020;47:563-8.
Chi CY, Lin CH, Ho MW, Ding JY, Huang WC, Shih HP, et al. Clinical manifestations, course, and outcome of patients with neutralizing anti-interferon-gamma autoantibodies and disseminated nontuberculous mycobacterial infections. Medicine (Baltimore). 2016;95:e3927.
Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, et al. Anti-IFN-gamma autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013;121:1357-66.
de Mutsert R, Jager KJ, Zoccali C, Dekker FW. The effect of joint exposures: examining the presence of interaction. Kidney Int. 2009;75:677-81.
VanderWeele TJ. The interaction continuum. Epidemiology. 2019;30:648-58.
Angkasekwinai N, Suputtamongkol Y, Phoompoung P, Pithukpakorn M, Wongswat E, Umrod P, et al. Clinical outcome and laboratory markers for predicting disease activity in patients with disseminated opportunistic infections associated with anti-interferon-gamma autoantibodies. PLoS One. 2019;14:e0215581.
Vignon-Pennamen M-D Sweet’s Syndrome. In: Wallach D, Vignon-Pennamen M-D, Valerio Marzano A (eds). Neutrophilic dermatoses. Cham: Springer International Publishing. 2018; 13-35. https://doi.org/10.1007/978-3-319-72649-6_3
Mobini N, Sadrolashrafi K, Michaels S. Neutrophilic dermatosis of the dorsal hands: report of a case and review of the literature. Case Rep Dermatol Med. 2019;2019:8301585.
Del Pozo J, Sacristan F, Martinez W, Paradela S, Fernandez-Jorge B, Fonseca E. Neutrophilic dermatosis of the hands: presentation of eight cases and review of the literature. J Dermatol. 2007;34:243-7.
Hong GH, Ortega-Villa AM, Hunsberger S, et al. Natural history and evolution of anti-interferon-gamma autoantibody-associated immunodeficiency syndrome in Thailand and the United States. Clin Infect Dis. 2020;71:53-62.
Giasuddin AS, El-Orfi AH, Ziu MM, El-Barnawi NY. Sweet’s syndrome: is the pathogenesis mediated by helper T cell type 1 cytokines? J Am Acad Dermatol. 1998;39:940-3.
Marzano AV, Cugno M, Trevisan V, Fanoni D, Venegoni L, Berti E, et al. Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. Clin Exp Immunol. 2010;162:100-7.
Marzano AV, Cugno M, Trevisan V, Lazzari R, Fanoni D, Berti E, et al. Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses. Int J Immunopathol Pharmacol. 2011;24:451-60.
Marzano AV, Fanoni D, Antiga E, Quaglino P, Caproni M, Crosti C, et al. Expression of cytokines, chemokines and other effector molecules in two prototypic autoinflammatory skin diseases, pyoderma gangrenosum and Sweet’s syndrome. Clin Exp Immunol. 2014;178:48-56.
Antiga E, Maglie R, Volpi W, Bianchi B, Berti E, Marzano AV, et al. T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol. 2017;189:383-91.
Costantini C, Micheletti A, Calzetti F, Perbellini O, Tamassia N, Albanesi C, et al. On the potential involvement of CD11d in co-stimulating the production of interferon-gamma by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3. Haematologica. 2011;96:1543-7.
Kawakami T, Ohashi S, Kawa Y, Takahama H, Ito M, Soma Y, et al. Elevated serum granulocyte colony-stimulating factor levels in patients with active phase of sweet syndrome and patients with active behcet disease: implication in neutrophil apoptosis dysfunction. Arch Dermatol. 2004;140:570-4.