Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis.
Acid Phosphatase
/ genetics
Androgens
/ pharmacology
Antineoplastic Agents, Hormonal
/ pharmacology
Biomarkers, Tumor
/ genetics
Cell Line, Tumor
Cell Proliferation
/ drug effects
Drug Resistance, Neoplasm
Early Detection of Cancer
Endoplasmic Reticulum
/ drug effects
Humans
Isoenzymes
Male
Predictive Value of Tests
Prostatic Neoplasms
/ drug therapy
Protein Conformation
Structure-Activity Relationship
androgen sensitivity
human prostatic acid phosphatase
prostate cancer
signal sequence
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
29 10 2021
29 10 2021
Historique:
received:
14
07
2021
revised:
18
09
2021
accepted:
04
10
2021
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
1
2
2022
Statut:
ppublish
Résumé
The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomics tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal sequence of secretory/membrane proteins with corresponding regions of functionally distinct signal sequence subtypes). This manipulation preferentially redirects proteins to different pathways of biogenesis at the endoplasmic reticulum (ER), magnifying normally difficult to detect subsets of the protein of interest. For PAcP, this technique reveals three forms identical in amino acid sequence but profoundly different in physiological functions, subcellular location, and biochemical properties. These three forms of PAcP can also occur with the wildtype PAcP signal sequence. Clinical specimens from patients with prostate cancer demonstrate that one form, termed PLPAcP, correlates with early prostate cancer. These findings confirm the analytical power of this method, implicate PLPAcP in prostate cancer pathogenesis, and suggest novel anticancer therapeutic strategies.
Identifiants
pubmed: 34677582
pii: 229977
doi: 10.1042/BSR20211646
pmc: PMC8536833
pii:
doi:
Substances chimiques
Androgens
0
Antineoplastic Agents, Hormonal
0
Biomarkers, Tumor
0
Isoenzymes
0
Acid Phosphatase
EC 3.1.3.2
prostatic acid phosphatase
EC 3.1.3.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 The Author(s).
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