LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells.
LINC00152
chronic lymphocytic leukemia
long non-coding RNAs
memory B cells
naïve B cells
Journal
Hematological oncology
ISSN: 1099-1069
Titre abrégé: Hematol Oncol
Pays: England
ID NLM: 8307268
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
18
10
2021
received:
20
09
2021
accepted:
19
10
2021
pubmed:
23
10
2021
medline:
15
2
2022
entrez:
22
10
2021
Statut:
ppublish
Résumé
Long non-coding RNAs are emerging as essential regulators of gene expression, but their role in normal and neoplastic B cells is still largely uncharacterized. Here, we report on the expression pattern of the LINC00152 in normal B cells and Chronic Lymphocytic Leukemia B cell clones. Higher LINC00152 levels were consistently observed in memory B cell populations when compared to naïve B cells in the normal tissues analyzed [peripheral blood (PB), tonsils, and spleen]. In addition, independent stimulation via Immunoglobulins (IG), CD40, or Toll-like Receptor 9 (TLR9) upregulated LINC00152 in PB B cells. The expression of LINC00152 in a cohort of 107 early stage Binet A CLL patients was highly variable and did not correlate with known prognostic markers or clinical evolution. TLR9 stimulation, but not CD40 or IG challenge, was able to upregulate LINC00152 expression in CLL cells. In addition, LINC00152 silencing in CLL cell lines expressing LINC00152 failed to induce significant cell survival or apoptosis changes. These data suggest that, in normal B cells, the expression of LINC00152 is regulated by immunomodulatory signals, which are only partially effective in CLL cells. However, LINC00152 does not appear to contribute to CLL cell expansion and/or survival in a cohort of newly diagnosed CLL patients.
Identifiants
pubmed: 34679195
doi: 10.1002/hon.2938
pmc: PMC9297877
doi:
Substances chimiques
Biomarkers, Tumor
0
RNA, Long Noncoding
0
long non-coding RNA Linc00152, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-47Subventions
Organisme : Italian Ministry of Health 5X1000
ID : 2014
Organisme : Italian Ministry of Health 5X1000
ID : 2015
Organisme : Italian Ministry of Health 5X1000
ID : 2016
Organisme : Italian Ministry of Health 5X1000
ID : 2017
Organisme : Associazione Italiana Leucemie Cosenza
ID : 2021
Organisme : Gilead Fellowship Program
ID : 2016
Organisme : Gilead Fellowship Program
ID : 2017
Organisme : Ricerca Corrente
ID : 2016
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 15426
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 16695
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 24365
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 9980
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 9980.
Informations de copyright
© 2021 The Authors. Hematological Oncology published by John Wiley & Sons Ltd.
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