PPAR-Gamma Activation May Inhibit the In Vivo Degeneration of Bioprosthetic Aortic and Aortic Valve Grafts under Diabetic Conditions.
Animals
Aorta
/ drug effects
Aortic Valve
/ pathology
Aortic Valve Stenosis
/ etiology
Blood Glucose
/ metabolism
Body Weight
Calcinosis
/ etiology
Diabetes Mellitus, Experimental
/ blood
Gene Expression Regulation
/ drug effects
Heart Valve Prosthesis
/ adverse effects
Materials Testing
PPAR gamma
/ metabolism
Pioglitazone
/ pharmacology
Rats, Wistar
PPAR-gamma
allograft
bioprosthetic valve
degeneration
diabetes mellitus
pioglitazone
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Oct 2021
14 Oct 2021
Historique:
received:
23
08
2021
revised:
07
10
2021
accepted:
11
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
28
12
2021
Statut:
epublish
Résumé
We aimed to examine the anti-calcification and anti-inflammatory effects of pioglitazone as a PPAR-gamma agonist on bioprosthetic-valve-bearing aortic grafts in a rat model of diabetes mellitus (DM). DM was induced in male Wistar rats by high-fat diet with an intraperitoneal streptozotocin (STZ) injection. The experimental group received additional pioglitazone, and controls received normal chow without STZ ( DM led to a significant media proliferation at 4 weeks. The additional administration of pioglitazone significantly increased circulating adiponectin levels and significantly reduced media thickness at 4 and 12 weeks, respectively ( Under diabetic conditions, pioglitazone leads to elevated circulating levels of adiponectin and to an inhibition of bioprosthetic graft degeneration, including lower expression of chondro-osteogenic genes, decreased media proliferation, and inhibited graft calcification in a small-animal model of DM.
Sections du résumé
BACKGROUND
BACKGROUND
We aimed to examine the anti-calcification and anti-inflammatory effects of pioglitazone as a PPAR-gamma agonist on bioprosthetic-valve-bearing aortic grafts in a rat model of diabetes mellitus (DM).
METHODS
METHODS
DM was induced in male Wistar rats by high-fat diet with an intraperitoneal streptozotocin (STZ) injection. The experimental group received additional pioglitazone, and controls received normal chow without STZ (
RESULTS
RESULTS
DM led to a significant media proliferation at 4 weeks. The additional administration of pioglitazone significantly increased circulating adiponectin levels and significantly reduced media thickness at 4 and 12 weeks, respectively (
CONCLUSIONS
CONCLUSIONS
Under diabetic conditions, pioglitazone leads to elevated circulating levels of adiponectin and to an inhibition of bioprosthetic graft degeneration, including lower expression of chondro-osteogenic genes, decreased media proliferation, and inhibited graft calcification in a small-animal model of DM.
Identifiants
pubmed: 34681744
pii: ijms222011081
doi: 10.3390/ijms222011081
pmc: PMC8538504
pii:
doi:
Substances chimiques
Blood Glucose
0
PPAR gamma
0
PPAR gamma, rat
0
Pioglitazone
X4OV71U42S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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