Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action.
antibacterial
antimicrobial peptides (AMPs)
biocompatibility
host defense peptides (HDPs)
immune modulation
resistance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Oct 2021
16 Oct 2021
Historique:
received:
20
09
2021
revised:
08
10
2021
accepted:
13
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory properties (e.g., anti-inflammatory activity). HDPs may hence provide a more robust treatment of bacterial infections. In this review, the advent of and the mechanisms that lead to antibiotic resistance will be described. HDP mechanisms of antibacterial and immunomodulatory action will be presented, with specific examples of how the HDP aurein 2.2 and a few of its derivatives, namely peptide 73 and cG4L73, function. Finally, resistance that may arise from a broader use of HDPs in a clinical setting and methods to improve biocompatibility will be briefly discussed.
Identifiants
pubmed: 34681833
pii: ijms222011172
doi: 10.3390/ijms222011172
pmc: PMC8538224
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Antimicrobial Cationic Peptides
0
Immunomodulating Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council
ID : RGPIN-2017-03831
Organisme : Deutsche Forschungsgemeinschaft
ID : 398967434-TRR 261
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