The "Adipo-Cerebral" Dialogue in Childhood Obesity: Focus on Growth and Puberty. Physiopathological and Nutritional Aspects.
Adipocytes
/ metabolism
Adipokines
/ metabolism
Adipose Tissue
/ metabolism
Animals
Biomarkers
Cerebral Cortex
/ metabolism
Child
Child Development
Child Nutritional Physiological Phenomena
Child, Preschool
Disease Susceptibility
Feedback, Physiological
Growth Hormone
/ metabolism
Humans
Insulin-Like Growth Factor I
/ metabolism
Kisspeptins
/ metabolism
Pediatric Obesity
/ etiology
Puberty
/ genetics
Signal Transduction
adipokines
adipose tissue
diet
growth
growth hormone deficiency
insulin-resistance
metabolic syndrome
personalized medicine
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Sep 2021
28 Sep 2021
Historique:
received:
20
07
2021
revised:
18
09
2021
accepted:
21
09
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
30
11
2021
Statut:
epublish
Résumé
Overweight and obesity in children and adolescents are overwhelming problems in western countries. Adipocytes, far from being only fat deposits, are capable of endocrine functions, and the endocrine activity of adipose tissue, resumable in adipokines production, seems to be a key modulator of central nervous system function, suggesting the existence of an "adipo-cerebral axis." This connection exerts a key role in children growth and puberty development, and it is exemplified by the leptin-kisspeptin interaction. The aim of this review was to describe recent advances in the knowledge of adipose tissue endocrine functions and their relations with nutrition and growth. The peculiarities of major adipokines are briefly summarized in the first paragraph; leptin and its interaction with kisspeptin are focused on in the second paragraph; the third paragraph deals with the regulation of the GH-IGF axis, with a special focus on the model represented by growth hormone deficiency (GHD); finally, old and new nutritional aspects are described in the last paragraph.
Identifiants
pubmed: 34684432
pii: nu13103434
doi: 10.3390/nu13103434
pmc: PMC8539184
pii:
doi:
Substances chimiques
Adipokines
0
Biomarkers
0
Kisspeptins
0
Insulin-Like Growth Factor I
67763-96-6
Growth Hormone
9002-72-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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