A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3.

Animals Antineoplastic Agents / pharmacology Ataxin-3 / drug effects Disease Models, Animal Glycoproteins / metabolism Neurodegenerative Diseases / drug therapy Zebrafish
Machado Joseph disease calpain polyglutamine spinocerebellar ataxia-3 zebrafish

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
29 09 2021
Historique:
received: 09 07 2021
revised: 22 09 2021
accepted: 22 09 2021
entrez: 23 10 2021
pubmed: 24 10 2021
medline: 5 1 2022
Statut: epublish

Résumé

Spinocerebellar ataxia type 3 (SCA3) is a hereditary ataxia caused by inheritance of a mutated form of the human

Identifiants

DOI: 10.3390/cells10102592 PMID: 34685571 PMC: PMC8533844
pubmed: 34685571
pii: cells10102592
doi: 10.3390/cells10102592
pmc: PMC8533844
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Glycoproteins 0
calpain inhibitors 0
Ataxin-3 EC 3.4.19.12

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Health and Medical Research Council
ID : 1069235
Organisme : National Health and Medical Research Council
ID : 1146750
Organisme : Macquarie University
ID : MQRES
Organisme : Macquarie University
ID : DVCR Start up

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Auteurs

Katherine J Robinson (KJ)

Neurodegeneration Treatment Team, Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney 2109, Australia.
ORCID: 0000-0001-9603-2696

Kristy Yuan (K)

Neurodegeneration Treatment Team, Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney 2109, Australia.

Stuart K Plenderleith (SK)

Neurodegeneration Treatment Team, Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney 2109, Australia.

Maxinne Watchon (M)

Neurodegeneration Treatment Team, Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney 2109, Australia.
ORCID: 0000-0002-8400-4994

Angela S Laird (AS)

Neurodegeneration Treatment Team, Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney 2109, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Ataxines › Ataxine-3 › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › A Novel Calpain Inhibitor Compound Has...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › A Novel Calpain Inhibitor Compound Has...