Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group.
Alagille syndrome
Biliary atresia
Diagnosis
Genetic liver disease
Inborn errors of metabolism
Jaundice
Monogenic liver disease
Newborn
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
03
05
2021
revised:
23
08
2021
accepted:
12
09
2021
pubmed:
25
10
2021
medline:
12
2
2022
entrez:
24
10
2021
Statut:
ppublish
Résumé
Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.
Identifiants
pubmed: 34688573
pii: S1590-8658(21)00780-5
doi: 10.1016/j.dld.2021.09.011
pii:
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-53Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.