Comparative study on the effect of aspirin, TP receptor antagonist and TxA
Arachidonic Acid
/ metabolism
Aspirin
/ pharmacology
Benzofurans
/ pharmacology
Carbazoles
/ pharmacology
Enzyme Inhibitors
/ pharmacology
Female
Humans
Male
Mammary Arteries
/ drug effects
Muscle, Smooth, Vascular
/ metabolism
Phenylephrine
/ pharmacology
Receptors, Prostaglandin
/ metabolism
Receptors, Thromboxane
/ antagonists & inhibitors
Saphenous Vein
/ drug effects
Sulfonamides
/ pharmacology
Thromboxane A2
/ pharmacology
Thromboxane-A Synthase
/ antagonists & inhibitors
Thromboxanes
/ antagonists & inhibitors
Vasoconstriction
/ drug effects
Aspirin
Internal mammary artery
Saphenous vein
TP receptor antagonist
TxA(2)
TxS inhibitor
Vascular tone
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
received:
02
09
2021
revised:
10
10
2021
accepted:
18
10
2021
pubmed:
25
10
2021
medline:
15
12
2021
entrez:
24
10
2021
Statut:
ppublish
Résumé
Thromboxane (TxA Using isolated organ bath, saphenous vein and internal mammary artery preparations were incubated with TP receptor antagonist, TxS inhibitor, aspirin, IP or EP4 receptor antagonist. Then prostaglandin (PG)E TP receptor antagonist inhibited the contraction induced by PGE TP receptor antagonist and TxS inhibitor are more effective to reduce contraction induced by different spasmogens in comparison to aspirin. Our results suggest that TP receptor antagonist and TxS inhibitor might have an advantage over aspirin due to their preventive effect on increased vascular reactivity observed in post-operative period of coronary artery bypass grafting.
Identifiants
pubmed: 34688694
pii: S0024-3205(21)01060-2
doi: 10.1016/j.lfs.2021.120073
pii:
doi:
Substances chimiques
Benzofurans
0
Carbazoles
0
Enzyme Inhibitors
0
Receptors, Prostaglandin
0
Receptors, Thromboxane
0
Sulfonamides
0
Thromboxanes
0
Phenylephrine
1WS297W6MV
Arachidonic Acid
27YG812J1I
Thromboxane A2
57576-52-0
Thromboxane-A Synthase
EC 5.3.99.5
furegrelate
KX4D9BZA6X
ramatroban
P1ALI72U6C
Aspirin
R16CO5Y76E
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120073Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.