Surging bloodstream infections and antimicrobial resistance during the first wave of COVID-19: a study in a large multihospital institution in the Paris region.
Antibiotic consumption
Antimicrobial resistance
Blood culture
Bloodstream infection incidence
COVID-19
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
26
06
2021
revised:
22
09
2021
accepted:
15
10
2021
pubmed:
25
10
2021
medline:
5
1
2022
entrez:
24
10
2021
Statut:
ppublish
Résumé
This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March-April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique - Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France. The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Up to a fourth of patients admitted in March-April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March-April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.
Identifiants
pubmed: 34688945
pii: S1201-9712(21)00821-3
doi: 10.1016/j.ijid.2021.10.034
pmc: PMC8531236
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-96Investigateurs
Guillaume Arlet
(G)
Laurence Armand Lefevre
(LA)
Alexandra Aubry
(A)
Laurent Belec
(L)
Béatrice Bercot
(B)
Stéphane Bonacorsi
(S)
Vincent Calvez
(V)
Emmanuelle Cambau
(E)
Etienne Carbonnelle
(E)
Stéphane Chevaliez
(S)
Jean-Winoc Decousser
(JW)
Constance Delaugerre
(C)
Diane Descamps
(D)
Florence Doucet-Populaire
(F)
Jean-Louis Gaillard
(JL)
Antoine Garbarg- Chenon
(AG)
Elyanne Gault
(E)
Jean-Louis Herrmann
(JL)
Vincent Jarlier
(V)
Jérôme Le Goff
(JL)
Jean-Christophe Lucet
(JC)
Jean-Luc Mainardi
(JL)
Anne-Geneviève Marcellin
(AG)
Laurence Morand-Joubert
(L)
Xavier Nassif
(X)
Jean-Michel Pawlotsky
(JM)
Jérôme Robert
(J)
Anne-Marie Roque Afonso
(AR)
Martin Rottman
(M)
Christine Rouzioux
(C)
Flore Rozenberg
(F)
François Simon
(F)
Nicolas Veziris
(N)
David Skurnik
(D)
Jean-Ralph Zahar
(JR)
Guilene Barnaud
(G)
Typhaine Billard Pomares
(TB)
Gaëlle Cuzon
(G)
Dominique Decré
(D)
Alexandra Doloy
(A)
Jean-Luc Donay
(JL)
Laurence Drieux-Rouzet
(L)
Isabelle Durand
(I)
Agnès Ferroni
(A)
Vincent Fihman
(V)
Nicolas Fortineau
(N)
Camille Gomart
(C)
Nathalie Grall
(N)
Christelle Guillet Caruba
(CG)
Françoise Jaureguy
(F)
Valérie Lalande
(V)
Luce Landraud
(L)
Véronique Leflon
(V)
Patricia Mariani
(P)
Liliana Mihaila
(L)
Didier Moissenet
(D)
Latifa Noussair
(L)
Isabelle Podglajen
(I)
Isabelle Poilane
(I)
Hélène Poupet
(H)
Emilie Rondinaud
(E)
Valérie Sivadon Tardy
(VS)
David Trystram
(D)
Charlotte Verdet
(C)
Emmanuelle Vigier
(E)
Sophie Vimont Billarant
(SV)
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.