Female Sex and Angiotensin-Converting Enzyme (ACE) Insertion/Deletion Polymorphism Amplify the Effects of Adiposity on Blood Pressure.
adiposity
angiotensin-converting enzyme
blood pressure
body mass index
sex characteristics
waist circumference
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
26
10
2021
medline:
19
1
2022
entrez:
25
10
2021
Statut:
ppublish
Résumé
The pathophysiological link between adiposity and blood pressure is not completely understood, and evidence suggests an influence of sex and genetic determinants. We aimed to identify the relationship between adiposity and blood pressure, independent of a robust set of lifestyle and metabolic factors, and to examine the modulating role of sex and Angiotensin-Converting Enzyme (ACE) insertion/deletion (I/D) polymorphisms. In the Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) study cohort, 1211 normotensive individuals, aged 30 to 60 years and followed-up after 3.3 years, were characterized for lifestyle and metabolic factors, body composition, and
Identifiants
pubmed: 34689596
doi: 10.1161/HYPERTENSIONAHA.121.18048
doi:
Substances chimiques
Peptidyl-Dipeptidase A
EC 3.4.15.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
36-46Investigateurs
R J Heine
(RJ)
J Dekker
(J)
S de Rooij
(S)
G Nijpels
(G)
W Boorsma
(W)
A Mitrakou
(A)
S Tournis
(S)
K Kyriakopoulou
(K)
P Thomakos
(P)
N Lalic
(N)
K Lalic
(K)
A Jotic
(A)
L Lukic
(L)
M Civcic
(M)
J Nolan
(J)
T P Yeow
(TP)
M Murphy
(M)
C DeLong
(C)
G Neary
(G)
M P Colgan
(MP)
M Hatunic
(M)
T Konrad
(T)
H Böhles
(H)
S Fuellert
(S)
F Baer
(F)
H Zuchhold
(H)
A Golay
(A)
E Harsch Bobbioni
(E)
V Barthassat
(V)
V Makoundou
(V)
T N O Lehmann
(TNO)
T Merminod
(T)
C Perry
(C)
F Neary
(F)
C MacDougall
(C)
K Shields
(K)
L Malcolm
(L)
M Laakso
(M)
U Salmenniemi
(U)
A Aura
(A)
R Raisanen
(R)
U Ruotsalainen
(U)
T Sistonen
(T)
M Laitinen
(M)
H Saloranta
(H)
S W Coppack
(SW)
N McIntosh
(N)
J Ross
(J)
L Pettersson
(L)
P Khadobaksh
(P)
M Laville
(M)
F Bonnet
(F)
A Brac de la Perriere
(A)
C Louche-Pelissier
(C)
C Maitrepierre
(C)
J Peyrat
(J)
S Beltran
(S)
A Serusclat
(A)
R Gabriel
(R)
E M Sánchez
(EM)
R Carraro
(R)
A Friera
(A)
B Novella
(B)
P Nilsson
(P)
M Persson
(M)
G Östling
(G)
O Melander
(O)
P Burri
(P)
P M Piatti
(PM)
L D Monti
(LD)
E Setola
(E)
E Galluccio
(E)
F Minicucci
(F)
A Colleluori
(A)
M Walker
(M)
I M Ibrahim
(IM)
M Jayapaul
(M)
D Carman
(D)
C Ryan
(C)
K Short
(K)
Y McGrady
(Y)
D Richardson
(D)
H Beck-Nielsen
(H)
P Staehr
(P)
V Vestergaard
(V)
C Olsen
(C)
L Hansen
(L)
G B Bolli
(GB)
F Porcellati
(F)
C Fanelli
(C)
P Lucidi
(P)
F Calcinaro
(F)
A Saturni
(A)
E Ferrannini
(E)
E Muscelli
(E)
S Pinnola
(S)
M Kozakova
(M)
A Casolaro
(A)
B D Astiarraga
(BD)
G Mingrone
(G)
C Guidone
(C)
A Favuzzi
(A)
P Di Rocco
(P)
C Anderwald
(C)
M Bischof
(M)
M Promintzer
(M)
M Krebs
(M)
M Mandl
(M)
A Hofer
(A)
A Luger
(A)
W Waldhäusl
(W)
M Roden
(M)
F Bonnet
(F)
S W Coppack
(SW)
J M Dekker
(JM)
E Ferrannini
(E)
A Mari
(A)
J Petrie
(J)
M Walker
(M)
P Gaffney
(P)
J Nolan
(J)
G Boran
(G)
C Olsen
(C)
L Hansen
(L)
H Beck-Nielsen
(H)
A Kok
(A)
J Dekker
(J)
S Patel
(S)
M Walker
(M)
A Gastaldelli
(A)
D Ciociaro
(D)
M Kozakova
(M)
M T Guillanneuf
(MT)
L Mhamdi
(L)
A Mari
(A)
L Mhamdi
(L)
L Landucci
(L)
S Hills
(S)
L Mota
(L)
A Mari
(A)
G Pacini
(G)
C Cavaggion
(C)
A Tura
(A)
S A Hills
(SA)
L Landucci
(L)
L Mota
(L)
Commentaires et corrections
Type : CommentIn