A rare case of severe gastroenteritis caused by Aeromonas hydrophila after colectomy in a patient with anti-Hu syndrome: a case report.
Aeromononas hydrophila
Anti-Hu syndrome
Case report
Cytotoxic enterotoxin
Gastroenteritis
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
24 Oct 2021
24 Oct 2021
Historique:
received:
19
05
2021
accepted:
12
10
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Aeromonas hydrophila is a gram-negative facultative anaerobic coccobacillus, which is an environmental opportunistic pathogen. A. hydrophila are involved in several infectious diseases such as gastroenteritis, septicemia and wound infections. However, gastroenteritis caused by Aeromonas spp. are rare and the clinical relevance of Aeromonas species in stool specimens is still under debate. Our case concerns a 32-year-old woman who presented at hospital with a worsening watery diarrhea and fever requiring intensive care. A cholera-like illness was diagnosed. The patient had a past history of an anti-Hu syndrome with a myenteric ganglionitis. A molecular multiplex RT-PCR (QIAstat-Dx Gastrointestinal Panel, QIAGEN) covering a broad spectrum of diverse gastrointestinal pathogens performed directly from the stool was negative but the stool culture revealed growth of A. hydrophila. Further investigations of the A. hydrophila strain in cell cultures revealed the presence of a cytotoxic enterotoxin. Although A. hydrophila rarely causes gastroenteritis, Aeromonas spp. should be considered as a causative agent of severe gastroenteritis with a cholera-like presentation. This case highlights the need to perform culture methods from stool samples when PCR-based methods are negative and gastrointestinal infection is suspected.
Sections du résumé
BACKGROUND
BACKGROUND
Aeromonas hydrophila is a gram-negative facultative anaerobic coccobacillus, which is an environmental opportunistic pathogen. A. hydrophila are involved in several infectious diseases such as gastroenteritis, septicemia and wound infections. However, gastroenteritis caused by Aeromonas spp. are rare and the clinical relevance of Aeromonas species in stool specimens is still under debate.
CASE PRESENTATION
METHODS
Our case concerns a 32-year-old woman who presented at hospital with a worsening watery diarrhea and fever requiring intensive care. A cholera-like illness was diagnosed. The patient had a past history of an anti-Hu syndrome with a myenteric ganglionitis. A molecular multiplex RT-PCR (QIAstat-Dx Gastrointestinal Panel, QIAGEN) covering a broad spectrum of diverse gastrointestinal pathogens performed directly from the stool was negative but the stool culture revealed growth of A. hydrophila. Further investigations of the A. hydrophila strain in cell cultures revealed the presence of a cytotoxic enterotoxin.
CONCLUSIONS
CONCLUSIONS
Although A. hydrophila rarely causes gastroenteritis, Aeromonas spp. should be considered as a causative agent of severe gastroenteritis with a cholera-like presentation. This case highlights the need to perform culture methods from stool samples when PCR-based methods are negative and gastrointestinal infection is suspected.
Identifiants
pubmed: 34689748
doi: 10.1186/s12879-021-06784-3
pii: 10.1186/s12879-021-06784-3
pmc: PMC8543949
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1097Informations de copyright
© 2021. The Author(s).
Références
Sci Rep. 2018 Sep 3;8(1):13044
pubmed: 30177854
J Clin Microbiol. 2003 Jun;41(6):2348-57
pubmed: 12791848
Ther Adv Chronic Dis. 2013 Sep;4(5):223-31
pubmed: 23997926
Infect Chemother. 2016 Dec;48(4):274-284
pubmed: 28032485
Int J Food Microbiol. 2011 Jan 5;144(3):538-45
pubmed: 21138783
mBio. 2013 Apr 23;4(2):e00064-13
pubmed: 23611906
Diagn Microbiol Infect Dis. 2016 May;85(1):98-101
pubmed: 26971634
Microbes Infect. 1999 Nov;1(13):1129-37
pubmed: 10572317
Brain. 2001 Jun;124(Pt 6):1138-48
pubmed: 11353730
Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22
pubmed: 21960820
PLoS One. 2013 Aug 27;8(8):e73140
pubmed: 24015295
Rev Inst Med Trop Sao Paulo. 2015 Jul-Aug;57(4):349-51
pubmed: 26422161
Front Microbiol. 2016 Sep 26;7:1522
pubmed: 27725813
Infection. 2007 Apr;35(2):59-64
pubmed: 17401708
Crit Rev Microbiol. 2007;33(1):89-100
pubmed: 17453931
Microbiol Immunol. 1995;39(9):655-61
pubmed: 8577278
Infect Immun. 1979 Mar;23(3):829-37
pubmed: 457260
Epidemiol Infect. 1997 Oct;119(2):121-6
pubmed: 9363009
J Med Microbiol. 1995 Jan;42(1):26-31
pubmed: 7739020
Inflamm Bowel Dis. 2015 Jan;21(1):71-8
pubmed: 25517595
Isr Med Assoc J. 2001 Feb;3(2):94-103
pubmed: 11344832
Appl Environ Microbiol. 2010 Apr;76(7):2313-25
pubmed: 20154106
Infect Immun. 1997 Oct;65(10):4299-308
pubmed: 9317040
FEMS Immunol Med Microbiol. 1997 Apr;17(4):217-23
pubmed: 9143879
Clin Infect Dis. 2000 May;30(5):770-8
pubmed: 10816147
Clin Neurol Neurosurg. 2020 Jul;194:105849
pubmed: 32388246
J Med Case Rep. 2018 Mar 17;12(1):71
pubmed: 29548295
Semin Diagn Pathol. 2019 May;36(3):187-192
pubmed: 31036328
J Microbiol Immunol Infect. 2012 Dec;45(6):398-403
pubmed: 23031536
J Clin Gastroenterol. 1989 Oct;11(5):552-4
pubmed: 2794433
Infect Immun. 1977 Dec;18(3):775-9
pubmed: 338490
J Clin Microbiol. 2000 Oct;38(10):3785-90
pubmed: 11015403
Clin Infect Dis. 1998 Aug;27(2):332-44
pubmed: 9709884
Microb Pathog. 1996 Nov;21(5):357-77
pubmed: 8938643
J Clin Microbiol. 2020 May 26;58(6):
pubmed: 32229601
Emerg Infect Dis. 2003 May;9(5):552-5
pubmed: 12737738
Infect Immun. 2002 Apr;70(4):1924-35
pubmed: 11895956
Microb Pathog. 1997 Oct;23(4):241-7
pubmed: 9344785
Clin Microbiol Rev. 2010 Jan;23(1):35-73
pubmed: 20065325
Surgery. 2017 Aug;162(2):325-348
pubmed: 28267992