Thyroid crisis caused by metastatic thyroid cancer: an autopsy case report.
Adenocarcinoma, Follicular
/ complications
Aged, 80 and over
Fatal Outcome
Female
Humans
Lung
/ diagnostic imaging
Lung Neoplasms
/ diagnostic imaging
Thyroid Carcinoma, Anaplastic
/ complications
Thyroid Crisis
/ diagnostic imaging
Thyroid Gland
/ diagnostic imaging
Thyroid Neoplasms
/ complications
Tomography, X-Ray Computed
Ultrasonography
Anaplastic thyroid carcinoma
Follicular thyroid carcinoma
Metastasis
Thyroid crisis
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
24 Oct 2021
24 Oct 2021
Historique:
received:
30
03
2021
accepted:
15
10
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Thyroid crisis is a life-threatening condition in thyrotoxic patients. Although differentiated thyroid cancer is one of the causes of hyperthyroidism, reports on thyroid crisis caused by thyroid cancer are quite limited. Here, we describe a case of thyroid crisis caused by metastatic thyroid cancer. A 91-year-old woman was admitted to our hospital because of loss of appetite. Two years prior to this hospitalization, she presented with subclinical thyrotoxicosis and was diagnosed with histologically unidentified thyroid cancer with multiple metastases, and she refused aggressive medical interventions. On admission, she exhibited extreme thyrotoxicosis, and the presence of fever, severe tachycardia, impaired consciousness, and heart failure revealed the presence of thyroid crisis. All thyroid autoantibodies were negative. Multidisciplinary conservative treatment was initiated; however, she died on the fifth day after admission. Autopsy revealed the presence of primary anaplastic thyroid carcinoma and multiple metastatic foci arising from follicular thyroid carcinoma. Both primary and metastatic follicular thyroid carcinoma likely induced thyrotoxicosis, which could have been exacerbated by anaplastic thyroid carcinoma. Even though the trigger of thyroid crisis in this patient is not clear, the aggravated progression of her clinical course suggests that careful monitoring of thyroid hormones and appropriate intervention are essential for patients with thyroid cancer.
Sections du résumé
BACKGROUND
BACKGROUND
Thyroid crisis is a life-threatening condition in thyrotoxic patients. Although differentiated thyroid cancer is one of the causes of hyperthyroidism, reports on thyroid crisis caused by thyroid cancer are quite limited. Here, we describe a case of thyroid crisis caused by metastatic thyroid cancer.
CASE PRESENTATION
METHODS
A 91-year-old woman was admitted to our hospital because of loss of appetite. Two years prior to this hospitalization, she presented with subclinical thyrotoxicosis and was diagnosed with histologically unidentified thyroid cancer with multiple metastases, and she refused aggressive medical interventions. On admission, she exhibited extreme thyrotoxicosis, and the presence of fever, severe tachycardia, impaired consciousness, and heart failure revealed the presence of thyroid crisis. All thyroid autoantibodies were negative. Multidisciplinary conservative treatment was initiated; however, she died on the fifth day after admission. Autopsy revealed the presence of primary anaplastic thyroid carcinoma and multiple metastatic foci arising from follicular thyroid carcinoma. Both primary and metastatic follicular thyroid carcinoma likely induced thyrotoxicosis, which could have been exacerbated by anaplastic thyroid carcinoma.
CONCLUSIONS
CONCLUSIONS
Even though the trigger of thyroid crisis in this patient is not clear, the aggravated progression of her clinical course suggests that careful monitoring of thyroid hormones and appropriate intervention are essential for patients with thyroid cancer.
Identifiants
pubmed: 34689780
doi: 10.1186/s12902-021-00875-7
pii: 10.1186/s12902-021-00875-7
pmc: PMC8543858
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
213Informations de copyright
© 2021. The Author(s).
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