Determinants of Ligand Specificity and Functional Plasticity in Type I Interferon Signaling.
Animals
Computer Simulation
Dimerization
Feedback, Physiological
Female
Humans
Inhibitory Concentration 50
Interferon-alpha
/ physiology
Interferon-beta
/ physiology
Kinetics
Ligands
Mice
Mice, Inbred C57BL
Models, Immunological
Protein Binding
Protein Interaction Mapping
Receptor Cross-Talk
/ physiology
Receptor, Interferon alpha-beta
/ physiology
STAT Transcription Factors
/ metabolism
Signal Transduction
/ physiology
Spleen
/ cytology
Suppressor of Cytokine Signaling 1 Protein
/ physiology
T-Lymphocytes
/ immunology
Ubiquitin Thiolesterase
cellular decision making
functional plasticity
ligand specificity
signal processing
type I interferon (IFN) signaling
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
07
2021
accepted:
14
09
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
28
12
2021
Statut:
epublish
Résumé
The Type I Interferon family of cytokines all act through the same cell surface receptor and induce phosphorylation of the same subset of response regulators of the STAT family. Despite their shared receptor, different Type I Interferons have different functions during immune response to infection. In particular, they differ in the potency of their induced anti-viral and anti-proliferative responses in target cells. It remains not fully understood how these functional differences can arise in a ligand-specific manner both at the level of STAT phosphorylation and the downstream function. We use a minimal computational model of Type I Interferon signaling, focusing on Interferon-
Identifiants
pubmed: 34691060
doi: 10.3389/fimmu.2021.748423
pmc: PMC8529159
doi:
Substances chimiques
Interferon-alpha
0
Ligands
0
STAT Transcription Factors
0
Suppressor of Cytokine Signaling 1 Protein
0
Receptor, Interferon alpha-beta
156986-95-7
Interferon-beta
77238-31-4
Ubiquitin Thiolesterase
EC 3.4.19.12
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
748423Informations de copyright
Copyright © 2021 Kirby, Parmar, Fathi, Marwah, Nayak, Cherepanov, MacParland, Feld, Altan-Bonnet and Zilman.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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