Antibody-mediated enzyme formation: Its legacy at age fifty-four.

Antibodies
activation antibody beta galactosidase conformation flexibility mutation paratope

Journal

Journal of molecular recognition : JMR
ISSN: 1099-1352
Titre abrégé: J Mol Recognit
Pays: England
ID NLM: 9004580

Informations de publication

Date de publication:
12 2021
Historique:
received: 09 07 2021
accepted: 20 07 2021
pubmed: 26 10 2021
medline: 17 3 2022
entrez: 25 10 2021
Statut: ppublish

Résumé

Antibody-mediated enzyme formation is a phenomenon first described in 1968 and further studied by molecular Immunologists and Biochemists over the following five decades. The present review is made mainly by analyzing the 27 articles concerned with AMEF that appeared over the course of 47 years, commenting 16 original figures selected to be re-printed in AMEF's Legacy. We, the reviewers, started by revisiting our own "insider's" experience of discovery, and followed by considering all results, our own and of members of other AMEF Labs. We had planned to conclude the review by correlating the various AMEF mutants to a detailed knowledge of the consensus betaGal structure. However, we became aware of several "robust" papers, published between 1989 and 2014, by authors outside of AMEF Labs. We familiarly called this surge: "The Second Wave" and adorned it with a doodle in Hokusai style. We were thrilled and happy to take them on board and properly examined their data. A team of this second wave had imagined unique uses for AMEF, and new doors to modern biotechnology. Another one had used AMEF as Tool and Marker to attain high levels of crystallography, solving puzzles of conformation, and ultimate structure. Together, they doubled our motivation to review AMEF. Serendipity gives us back the pleasure of finding, a treat at any age.

Identifiants

DOI: 10.1002/jmr.2931 PMID: 34693572 PMC: PMC9286546
pubmed: 34693572
doi: 10.1002/jmr.2931
pmc: PMC9286546
doi:

Substances chimiques

Antibodies 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2931

Informations de copyright

© 2021 The Authors. Journal of Molecular Recognition published by John Wiley & Sons Ltd.

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Auteurs

Roberto Strom (R)

School of Medicine, Universita' La Sapienza, Rome, Italy.

Franco Celada (F)

School of Medicine, University of Genoa, Genoa, Italy.
Grossman School of Medicine, NYU, New York, New York, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Antibody-mediated enzyme formation: Its legacy...