Characteristics and outcomes of SARS-CoV-2 infection in Victorian children at a tertiary paediatric hospital.


Journal

Journal of paediatrics and child health
ISSN: 1440-1754
Titre abrégé: J Paediatr Child Health
Pays: Australia
ID NLM: 9005421

Informations de publication

Date de publication:
04 2022
Historique:
revised: 10 08 2021
received: 17 03 2021
accepted: 17 09 2021
pubmed: 26 10 2021
medline: 5 4 2022
entrez: 25 10 2021
Statut: ppublish

Résumé

Victoria experienced two 'waves' of COVID-19 between March and September 2020 and more cases than any other jurisdiction in Australia. Although world-wide reports of COVID-19 reflect that children are less likely to experience severe disease compared with adults, hospitalisations and deaths have been reported. We report testing and outcomes of children with SARS-CoV-2 infection presenting to a tertiary paediatric hospital in Melbourne. We conducted a prospective cohort study at The Royal Children's Hospital (RCH), including all children and adolescents (aged 0-18 years) who presented and were tested for SARS-CoV-2 over a 6-month period, between 21 March 2020, up to the 21 September 2020. Detailed epidemiological and clinical data were recorded. A total of 19 708 tests for SARS-CoV-2 were performed in 14 419 patients. One hundred and eighty patients tested positive for SARS-CoV-2 (1.2%). 110 (61%) were symptomatic, 60 (33%) were asymptomatic and 10 (6%) were pre-symptomatic. Close contacts of a positive case were associated with a higher risk of a testing positive for SARS-CoV-2 (120/2027 (6%) vs. 60/14589 (0.4%), RD 5.5 (95% CI 4.5 to 6.5), P < 0.001). Eighteen (10%) SARS-CoV-2-positive patients were admitted to hospital with one patient requiring intensive care. All patients recovered fully with no deaths. In Victorian children presenting to a tertiary hospital, SARS-CoV-2 infection caused predominantly mild or asymptomatic infection, with most children not requiring hospitalisation.

Identifiants

pubmed: 34693586
doi: 10.1111/jpc.15786
pmc: PMC8662161
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

618-623

Informations de copyright

© 2021 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

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Auteurs

Shidan Tosif (S)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Laila F Ibrahim (LF)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Hospital-in-the-Home Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Rebecca Hughes (R)

Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Daryl R Cheng (D)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Danielle Wurzel (D)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Respiratory Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Isabella Overmars (I)

Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.

Andrew C Steer (AC)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Infectious Diseases Unit, Department of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Penelope A Bryant (PA)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Hospital-in-the-Home Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Infectious Diseases Unit, Department of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Trevor Duke (T)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Intensive Care Unit, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Stuart Lewena (S)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Emergency Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Emergency Research, Clinical Sciences, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.

Franz E Babl (FE)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Emergency Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Emergency Research, Clinical Sciences, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.

Sarah McNab (S)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Nigel Crawford (N)

Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Infection and Immunity, Murdoch Children 's Research Institute, Melbourne, Victoria, Australia.
Departments of General Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia.

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