Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
11 11 2021
11 11 2021
Historique:
pubmed:
26
10
2021
medline:
15
12
2021
entrez:
25
10
2021
Statut:
ppublish
Résumé
Snyder Robinson Syndrome (SRS) is a rare disease associated with a defective spermine synthase gene and low intracellular spermine levels. In this study, a spermine replacement therapy was developed using a spermine prodrug that enters cells
Identifiants
pubmed: 34695351
doi: 10.1021/acs.jmedchem.1c00419
pmc: PMC9115777
mid: NIHMS1802782
doi:
Substances chimiques
Prodrugs
0
Spermine
2FZ7Y3VOQX
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15593-15607Subventions
Organisme : NINDS NIH HHS
ID : R01 NS109640
Pays : United States
Organisme : NIH HHS
ID : S10 OD021758
Pays : United States
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