Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia.
Anti-Bacterial Agents
/ therapeutic use
Azithromycin
/ therapeutic use
Child, Preschool
Chlamydia trachomatis
/ isolation & purification
Ethiopia
/ epidemiology
Eye
/ microbiology
Female
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases
/ drug therapy
Male
Neglected Diseases
/ drug therapy
Prevalence
Trachoma
/ drug therapy
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
25 10 2021
25 10 2021
Historique:
received:
09
08
2021
accepted:
31
08
2021
pubmed:
26
10
2021
medline:
22
2
2022
entrez:
25
10
2021
Statut:
epublish
Résumé
Infants ages < 6 months do not receive azithromycin as part of trachoma control and thus may serve as an infection reservoir in persistently endemic districts. The aim of this study was to determine the population-based Chlamydia trachomatis infection prevalence and infectious load among infants ages 1-12 months in persistently trachoma endemic districts in Amhara, Ethiopia. Across six districts, 475 infants were enumerated, and of these 464 (97.7%) were swabbed for infection testing. The C. trachomatis infection prevalence in the study area among infants was 0.2% (95% CI: 0.0-1.5). Among children ages 0-5 years positive for C. trachomatis, the median load was 31 elementary bodies (EB) (Inter quartile range: 7-244 EB), and the infection-positive infant had a load of 7,755 EB. While it is worth reconsidering azithromycin treatment recommendations for the potential mortality benefits, these results do not support lowering the treatment age for trachoma control.
Identifiants
pubmed: 34695789
doi: 10.4269/ajtmh.21-0873
pmc: PMC8733485
doi:
Substances chimiques
Anti-Bacterial Agents
0
Azithromycin
83905-01-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-65Références
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