Genome Editing Strategies to Protect Livestock from Viral Infections.
CRISPR/Cas
disease resistance
gene editing
genome editing
host–pathogen interactions
livestock viruses
viral interference
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
04 10 2021
04 10 2021
Historique:
received:
27
08
2021
revised:
27
09
2021
accepted:
29
09
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
The livestock industry is constantly threatened by viral disease outbreaks, including infections with zoonotic potential. While preventive vaccination is frequently applied, disease control and eradication also depend on strict biosecurity measures. Clustered regularly interspaced palindromic repeats (CRISPR) and associated proteins (Cas) have been repurposed as genome editors to induce targeted double-strand breaks at almost any location in the genome. Thus, CRISPR/Cas genome editors can also be utilized to generate disease-resistant or resilient livestock, develop vaccines, and further understand virus-host interactions. Genes of interest in animals and viruses can be targeted to understand their functions during infection. Furthermore, transgenic animals expressing CRISPR/Cas can be generated to target the viral genome upon infection. Genetically modified livestock can thereby reduce disease outbreaks and decrease zoonotic threats.
Identifiants
pubmed: 34696426
pii: v13101996
doi: 10.3390/v13101996
pmc: PMC8539128
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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