Role of Potassium Ions in Regulation of Calcium-Activated Chloride Channels.
Purkinje cells of the rat cerebellum
calcium-activated chloride channels (CaCCs)
patch-clamp method
potassium ions
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
11
04
2021
accepted:
23
05
2021
revised:
22
05
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
5
2
2022
Statut:
ppublish
Résumé
Using the patch-clamp method in the whole cell configuration, it was shown that external potassium ions play an important role in the regulation of calcium-activated chloride channels (CaCCs). A clear dependence of the conductivity of the СаССs on the external potassium concentration was shown. The effect of external potassium in the range 0-15 mM on the conductivity of chloride channels was significantly greater than the effect it had on other ionic currents (sodium or potassium). There is reason to believe that these changes in the conductivity of CaCCs may contribute to the development of pathophysiological processes such as hypokalemia or hyperkalemia.
Identifiants
pubmed: 34697736
doi: 10.1134/S1607672921050215
pii: 10.1134/S1607672921050215
doi:
Substances chimiques
Chloride Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-323Informations de copyright
© 2021. Pleiades Publishing, Ltd.
Références
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