ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
28 Oct 2024
Historique:
received: 03 04 2024
accepted: 04 10 2024
medline: 29 10 2024
pubmed: 29 10 2024
entrez: 29 10 2024
Statut: epublish

Résumé

Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates surgical procedures and tracheal intubation, adequate recovery of muscle function after surgery is required to support pulmonary function, and even mild residual neuromuscular block increases the risk of severe postoperative pulmonary complications. While recovery of muscle function after surgery involving neuromuscular blocking agents can be monitored and, in addition, be accelerated by use of current antagonists (reversal agents), there is a clear clinical need for a safe drug to antagonize all types of neuromuscular blocking agents. Here, we show that inhibition of the skeletal muscle-specific chloride ion (Cl

Identifiants

pubmed: 39468073
doi: 10.1038/s41467-024-53237-x
pii: 10.1038/s41467-024-53237-x
doi:

Substances chimiques

Chloride Channels 0
CLC-1 channel 0
Neuromuscular Blocking Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9289

Subventions

Organisme : Innovationsfonden (Innovation Fund Denmark)
ID : 0174-00051A

Informations de copyright

© 2024. The Author(s).

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Auteurs

Anders Riisager (A)

NMD Pharma, Aarhus, Denmark.

Judith Ceelen (J)

NMD Pharma, Aarhus, Denmark.

Ole Bækgaard Nielsen (OB)

Department of Public Health, Aarhus University, Aarhus, Denmark.

Sorin J Brull (SJ)

Department of Anesthesiology, Mayo Clinic College of Medicine and Science, Jacksonville, USA.

Hans D de Boer (HD)

Department of Anesthesiology, Pain Medicine and Procedural Sedation and Analgesia, Martini General Hospital Groningen, Groningen, the Netherlands.

Thomas Holm Pedersen (TH)

NMD Pharma, Aarhus, Denmark. thp@nmdpharma.com.
Department of Biomedicine, Aarhus University, Aarhus, Denmark. thp@nmdpharma.com.

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