A comparison of emulsifiers for the formation of oil-in-water emulsions: stability of the emulsions within 9 h after production and MR signal properties.
DWI
Emulsifiers
Fat water MRI
Oil-in-water emulsions
Relaxometry
Journal
Magma (New York, N.Y.)
ISSN: 1352-8661
Titre abrégé: MAGMA
Pays: Germany
ID NLM: 9310752
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
24
06
2021
accepted:
13
10
2021
revised:
12
10
2021
pubmed:
27
10
2021
medline:
15
6
2022
entrez:
26
10
2021
Statut:
ppublish
Résumé
To provide a basis for the selection of suitable emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. Three different emulsifiers were investigated with regard to their ability to stabilize tissue-like oil-in-water emulsions. Furthermore, MR signal properties of the emulsifiers themselves and influences on relaxation times and ADC values of the aqueous phase were investigated. Polysorbate 60, sodium dodecyl sulfate (SDS) and soy lecithin were used as emulsifiers. MR characteristics of emulsifiers were assessed in aqueous solutions and their function as a stabilizer was examined in oil-in-water emulsions of varying fat content (10, 20, 30, 40, 50%). Stability and homogeneity of the oil-in-water emulsions were evaluated with a delay of 3 h and 9 h after preparation using T Emulsions stabilized by polysorbate 60 or soy lecithin were stable and homogeneous across all tested fat fractions. In contrast, emulsions with SDS showed a significantly lower stability and homogeneity. Recorded T Lecithin is suggested as the preferred emulsifier of oil-in-water emulsions in MRI as it shows a high stabilizing ability and remains invisible in MRI experiments. In addition, lecithin is suitable as an alternative means of adjusting relaxation times and ADC values of water.
Identifiants
pubmed: 34698962
doi: 10.1007/s10334-021-00970-9
pii: 10.1007/s10334-021-00970-9
pmc: PMC9188495
doi:
Substances chimiques
Emulsifying Agents
0
Emulsions
0
Lecithins
0
Polysorbates
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-410Informations de copyright
© 2021. The Author(s).
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