Metastatic tumors to the pancreas, a 12-year single institution review.
metastases
pancreas
secondary
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
23
08
2021
received:
25
06
2021
accepted:
24
08
2021
pubmed:
27
10
2021
medline:
25
2
2022
entrez:
26
10
2021
Statut:
ppublish
Résumé
Tumors of the pancreas are often primary in nature, but are occasionally proven to be secondary. We report a 12-year review of all pancreatic tumors shown to be metastatic at the University of Colorado. The electronic pathology database was searched between 2008 and 2020, for all pancreatic fine-needle aspiration cases at the University of Colorado to identify and review metastatic tumors to the pancreas. Additional data points to include age, sex, radiographic features, and clinical management were analyzed. Our data retrieval identified 39 metastatic tumors to the pancreas comprised of 12 (31%) renal cell carcinomas, 6 (15%) lung carcinomas, and 5 (13%) melanomas with the remainder of tumors originating from a variety of other sites. The most common location of these metastases within the pancreas was the pancreatic head (49%) followed by the body (20%). Eighty-five percentage of cases presented with a single radiographically identified mass. While the majority of pancreatic tumors represent primary processes, metastatic tumors to the pancreas represent a possible pitfall. The most common tumors to metastasize to the pancreas in this series were renal cell carcinoma, lung carcinoma, and melanoma. General awareness of the most frequent tumors to metastasize to the pancreas is practical when faced with a pancreatic lesion that could represent a metastasis, or in the absence of clinical history.
Sections du résumé
BACKGROUND
BACKGROUND
Tumors of the pancreas are often primary in nature, but are occasionally proven to be secondary. We report a 12-year review of all pancreatic tumors shown to be metastatic at the University of Colorado.
METHOD
METHODS
The electronic pathology database was searched between 2008 and 2020, for all pancreatic fine-needle aspiration cases at the University of Colorado to identify and review metastatic tumors to the pancreas. Additional data points to include age, sex, radiographic features, and clinical management were analyzed.
RESULTS
RESULTS
Our data retrieval identified 39 metastatic tumors to the pancreas comprised of 12 (31%) renal cell carcinomas, 6 (15%) lung carcinomas, and 5 (13%) melanomas with the remainder of tumors originating from a variety of other sites. The most common location of these metastases within the pancreas was the pancreatic head (49%) followed by the body (20%). Eighty-five percentage of cases presented with a single radiographically identified mass.
CONCLUSION
CONCLUSIONS
While the majority of pancreatic tumors represent primary processes, metastatic tumors to the pancreas represent a possible pitfall. The most common tumors to metastasize to the pancreas in this series were renal cell carcinoma, lung carcinoma, and melanoma. General awareness of the most frequent tumors to metastasize to the pancreas is practical when faced with a pancreatic lesion that could represent a metastasis, or in the absence of clinical history.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1233-1236Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Ballarin R, Spaggiari M, Cautero N, et al. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroeneterol. 2011;17:4747-4756.
Masetti M, Zanini N, Martuzzi F, et al. Analysis of prognostic factors in metastatic tumors of the pancreas. Pancreas J. 2010;29(2):135-143.
Nakamura E, Shimizu M, Itoh T, Manabe T. Secondary tumors of the pancreas: Clinicopathologic study of 103 autopsy cases of Japanese patients. Pathol Int. 2001;51:686-690.
DeWitt J, Jowell P, Leblanc J, et al. EUS-guided FNA of the pancreas: a multicenter experience. Gastrointest Endosc. 2005;61(6):689-696.
Ardengh JC, Lopes CV, Kemp R, Venco F, de Lima-Filho ER, dos Santos JS. Accuracy of endoscopic ultrasound guided fine needle aspiration in the suspicion of pancreatic metastases. Gastroenterology. 2013;13:63.
Vargas-Jiménez J, Vargas-Madrigal J, Arias-Mora R, Ulate-Ovares D, Solis-Ugalde B. Pancreatic metastasis from malignant melanoma: not all that glitters is gold. Case Rep Gastroenterol. 2021;15(1):131-136.
Layfield LJ, Hirschowitz SL, Adler DG. Metastatic disease to pancreas documented by endoscopic ultrasound guided fine-needle aspiration, a seven-year experience. Diagn Cytopathol. 2010;40(3):228-233.
Waters L, Si Q, Caraway N, Mody D, Staerkel G, Sneige N. Secondary tumors of the pancreas diagnosed by endoscopic ultrasound guided fine needle aspiration: a 10 year experience. Diagn Cytopathol. 2014;24(9):738-743.
Minni F, Casadei R, Perenze B, et al. Pancreatic metastases: observations of three cases and review of literature. Pancreatology. 2004;4:509-520.
Robbins EG, Franceschi D, Barkin JS. Solitary metastatic tumors to the pancreas: a case report and review of the literature. Am J Gastroenterol. 1996;91(11):2414-2417.
Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary tumors of the pancreas: an analysis of surgical and autopsy database and review of the literature. Virchows Archive. 2004;444:527-535.
Richmond AM, Mehrotra S. Two unusual variants of pancreatic neuroendocrine tumor and their potential pitfalls on fine-needle aspiration. Diagn Cytopathol. 2017;45:371-378.
Chung JB, Chung DK, Kim DY, et al. Percutaneous fine needle aspiration biopsy of pancreatic Cancer guided by ultrasonography. Korean J Intern Med. 1989;2(2):125-129.
Sperti C, Moletta L, Patanè G. Metastatic tumors to the pancreas: the role of surgery. Gastrointestinal Oncology. 2014;6(10):381-392.
Machado NO, Chopra P. Pancreatic metastasis from renal carcinoma managed by Whipple resection. A case report and literature review of metastatic pattern, surgical management and outcome. JOP. 2009;10(4):413-418.
Goyal J, Lipson EJ, Rezaee N. Surgical resection of malignant melanoma metastatic to the pancreas: case series and review of literature. J Gastrointest Cancer. 2012;43(3):431-436.
Pan B, Lee Y, Rodriguez T, Lee J, Saif MW. Secondary tumors of the pancreas: a case series. Anticancer Res. 2012;32:1449-1452.