Alcohol and the brain: from genes to circuits.
alcohol
central nervous system
epigenetics
intracellular signaling
neural circuits
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
21
04
2021
revised:
08
09
2021
accepted:
30
09
2021
pubmed:
28
10
2021
medline:
9
4
2022
entrez:
27
10
2021
Statut:
ppublish
Résumé
Alcohol use produces wide-ranging and diverse effects on the central nervous system. It influences intracellular signaling mechanisms, leading to changes in gene expression, chromatin remodeling, and translation. As a result of these molecular alterations, alcohol affects the activity of neuronal circuits. Together, these mechanisms produce long-lasting cellular adaptations in the brain that in turn can drive the development and maintenance of alcohol use disorder (AUD). We provide an update on alcohol research, focusing on multiple levels of alcohol-induced adaptations, from intracellular changes to changes in neural circuits. A better understanding of how alcohol affects these diverse and interlinked mechanisms may lead to the identification of novel therapeutic targets and to the development of much-needed novel and efficacious treatment options.
Identifiants
pubmed: 34702580
pii: S0166-2236(21)00187-9
doi: 10.1016/j.tins.2021.09.006
pmc: PMC8616825
mid: NIHMS1747170
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1004-1015Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027474
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA045103
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA016848
Pays : United States
Organisme : NIAAA NIH HHS
ID : K99 AA028577
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027682
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflicts of interest.
Références
Genes Brain Behav. 2021 Feb 28;:e12729
pubmed: 33641239
Neurotherapeutics. 2020 Jan;17(1):4-16
pubmed: 31617071
Neuropharmacology. 2016 Nov;110(Pt A):190-197
pubmed: 27450094
Neuropsychopharmacology. 2018 Mar;43(4):838-850
pubmed: 28589966
Biol Psychiatry. 2020 Dec 15;88(12):898-909
pubmed: 32331824
Neuropharmacology. 2018 Sep 15;140:162-173
pubmed: 30075159
J Neurosci. 2016 Jan 20;36(3):701-13
pubmed: 26791202
Neuropsychopharmacology. 2019 May;44(6):1084-1092
pubmed: 30555162
Pharmacol Rev. 2016 Apr;68(2):242-63
pubmed: 26772794
Neuropsychopharmacology. 2017 Apr;42(5):1024-1036
pubmed: 27620551
Nat Neurosci. 2013 Nov;16(11):1530-6
pubmed: 23584741
Neuron. 2017 Dec 20;96(6):1223-1238
pubmed: 29268093
J Neurosci. 2015 Apr 15;35(15):6153-64
pubmed: 25878287
Nat Rev Drug Discov. 2019 Oct;18(10):770-796
pubmed: 31388135
Nature. 2019 Oct;574(7780):717-721
pubmed: 31645761
Neuropsychopharmacology. 2018 Aug;43(9):1840-1850
pubmed: 29748627
Sci Adv. 2021 Apr 9;7(15):
pubmed: 33837086
Front Genet. 2018 Sep 24;9:402
pubmed: 30319688
Lancet. 2019 Aug 31;394(10200):781-792
pubmed: 31478502
Nat Rev Neurosci. 2016 Sep;17(9):576-91
pubmed: 27444358
Science. 2018 Jun 22;360(6395):1321-1326
pubmed: 29930131
Neuropsychopharmacology. 2019 May;44(6):1132-1140
pubmed: 30647448
Mol Psychiatry. 2021 Jun;26(6):2175-2186
pubmed: 32144357
Alcohol Clin Exp Res. 2020 May;44(5):1037-1045
pubmed: 32154588
Neuropharmacology. 2017 Aug 1;122:74-84
pubmed: 28174112
Addict Biol. 2017 May;22(3):766-778
pubmed: 26786379
J Neurosci. 2020 Jan 15;40(3):632-647
pubmed: 31744862
Nat Commun. 2019 Mar 18;10(1):1238
pubmed: 30886240
Sci Rep. 2018 Jul 10;8(1):10376
pubmed: 29991681
J Neurosci. 2017 Mar 29;37(13):3646-3660
pubmed: 28270566
Neuropsychopharmacology. 2021 Jul;46(8):1432-1441
pubmed: 33452430
Nat Neurosci. 1999 Nov;2(11):997-1002
pubmed: 10526339
Addict Biol. 2019 May;24(3):335-343
pubmed: 29726054
Alcohol Clin Exp Res. 2016 Jun;40(6):1251-61
pubmed: 27147118
eNeuro. 2016 Oct 31;3(5):
pubmed: 27822501
Nat Commun. 2020 Jul 28;11(1):3764
pubmed: 32724058
Mol Psychiatry. 2018 May;23(5):1303-1319
pubmed: 28397836
Neuron. 2018 May 2;98(3):512-520.e6
pubmed: 29656870
Mol Psychiatry. 2017 Oct;22(10):1376-1384
pubmed: 28937693
Neuropharmacology. 2017 Aug 1;122:189-200
pubmed: 28118989
Science. 2019 Nov 22;366(6468):1008-1012
pubmed: 31754002
Neuropsychopharmacology. 2019 Jan;44(2):415-424
pubmed: 30008470
Transl Psychiatry. 2017 Jan 10;7(1):e994
pubmed: 28072409
Neuron. 2018 Dec 5;100(5):1209-1223.e4
pubmed: 30482693
Neuropsychopharmacology. 2017 Aug;42(9):1800-1812
pubmed: 28139680
Cereb Cortex. 2019 Apr 1;29(4):1736-1751
pubmed: 30721969
Genetics. 2020 May;215(1):103-116
pubmed: 32132098
Nature. 2019 Mar;567(7749):535-539
pubmed: 30867594
Addict Biol. 2017 Sep;22(5):1191-1204
pubmed: 27183824
PLoS Biol. 2019 Apr 16;17(4):e2006421
pubmed: 30990816
Biol Psychiatry. 2016 Mar 15;79(6):443-51
pubmed: 25861702
Biol Psychiatry. 2016 Mar 15;79(6):463-73
pubmed: 26204799
Nat Commun. 2020 Sep 14;11(1):4634
pubmed: 32929078
Nat Commun. 2019 Sep 2;10(1):3934
pubmed: 31477694
J Neurosci. 2019 Oct 2;39(40):7947-7957
pubmed: 31375540
Front Pharmacol. 2017 Aug 15;8:533
pubmed: 28860990
Biol Psychiatry. 2020 Jun 1;87(11):967-978
pubmed: 31937415
Nat Commun. 2021 Jul 27;12(1):4407
pubmed: 34315870
Nat Neurosci. 2020 Jul;23(7):809-818
pubmed: 32451486
Nat Commun. 2020 May 22;11(1):2555
pubmed: 32444624
Genes Brain Behav. 2017 Sep;16(7):699-708
pubmed: 28398003
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4085-93
pubmed: 26170296
Cell. 2017 Mar 9;168(6):960-976
pubmed: 28283069
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377
pubmed: 27911795
Neuropsychopharmacology. 2016 Jun;41(7):1831-40
pubmed: 26758662
Sci Adv. 2020 May 06;6(19):eaax7060
pubmed: 32494694
Mol Psychiatry. 2021 Apr;26(4):1152-1161
pubmed: 31462767
J Neurosci. 2017 Sep 6;37(36):8742-8754
pubmed: 28821667
Neuropsychopharmacology. 2018 Aug;43(9):1805-1812
pubmed: 29463912
J Neurosci. 2020 May 13;40(20):3949-3968
pubmed: 32277042
Nat Neurosci. 2018 Mar;21(3):373-383
pubmed: 29434375
Mol Psychiatry. 2021 Jun;26(6):2187-2199
pubmed: 32099099
Alcohol Clin Exp Res. 2018 Dec;42(12):2281-2297
pubmed: 30320893
Nat Commun. 2018 Apr 3;9(1):1318
pubmed: 29615610
Mol Psychiatry. 2021 Jun;26(6):2350-2362
pubmed: 33432187
eNeuro. 2019 Dec 3;6(6):
pubmed: 31740576
Biol Psychiatry. 2020 Dec 15;88(12):910-921
pubmed: 32680583
Neuron. 2019 Sep 4;103(5):891-908.e6
pubmed: 31277924
Nat Commun. 2018 Jan 15;9(1):211
pubmed: 29335427
Alcohol. 2015 Dec;49(8):795-802
pubmed: 26095589
Hum Mol Genet. 2020 May 8;29(7):1144-1153
pubmed: 32142123
Transl Psychiatry. 2019 Feb 4;9(1):71
pubmed: 30718457
Pharmacogenomics J. 2018 Jul;18(4):578-589
pubmed: 29305589
Biol Psychiatry. 2018 Aug 1;84(3):193-201
pubmed: 29198469
Nat Commun. 2016 Sep 26;7:12867
pubmed: 27666021
Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2149-2159
pubmed: 31937658
Neuropsychopharmacology. 2019 Feb;44(3):526-537
pubmed: 30390064
Sci Adv. 2021 Aug 18;7(34):
pubmed: 34407947
J Neurosci. 2019 Sep 4;39(36):7206-7217
pubmed: 31315945
Cell Metab. 2014 Mar 4;19(3):373-9
pubmed: 24508508
Alcohol. 2017 Aug;62:1-9
pubmed: 28755746
Genes Brain Behav. 2017 Jan;16(1):139-148
pubmed: 27906494
Prog Transplant. 2001 Mar;11(1):29-32
pubmed: 11357554
Mol Psychiatry. 2017 Jan;22(1):89-101
pubmed: 26952865
Neuropsychopharmacology. 2021 Jan;46(2):351-359
pubmed: 32663841
Neuropharmacology. 2019 Sep 1;155:89-97
pubmed: 31121177
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20093-8
pubmed: 21041654
Nat Metab. 2021 Mar;3(3):337-351
pubmed: 33758417
J Neurosci. 2020 Jul 1;40(27):5196-5207
pubmed: 32482639
Sci Adv. 2020 Mar 18;6(12):eaaz1050
pubmed: 32206720
Neuropharmacology. 2020 May 1;167:107984
pubmed: 32023486
Cell Metab. 2016 Feb 9;23(2):344-9
pubmed: 26724861
Psychopharmacology (Berl). 2018 Jun;235(6):1727-1743
pubmed: 29654346
Elife. 2019 Dec 11;8:
pubmed: 31820733
Transl Psychiatry. 2021 Jan 5;11(1):2
pubmed: 33414398
Front Mol Neurosci. 2019 Aug 13;12:197
pubmed: 31456662
Addict Biol. 2021 Mar;26(2):e12890
pubmed: 32135570
J Neurosci. 2020 Aug 12;40(33):6409-6427
pubmed: 32669355
Neuropharmacology. 2019 Mar 1;146:289-299
pubmed: 30419244
Addict Biol. 2019 Nov;24(6):1227-1234
pubmed: 30536923
Cell Rep. 2019 Oct 29;29(5):1147-1163.e5
pubmed: 31665630
Handb Exp Pharmacol. 2018;248:213-238
pubmed: 29675581
Pharmacol Res. 2020 Feb;152:104609
pubmed: 31862477
Sci Signal. 2020 Sep 22;13(650):
pubmed: 32963013
Addict Biol. 2017 May;22(3):665-678
pubmed: 26752591
Trends Neurosci. 2021 Feb;44(2):122-135
pubmed: 33168235
Neuropsychopharmacology. 2018 Jun;43(7):1539-1547
pubmed: 29497165
Nat Neurosci. 2013 Aug;16(8):1111-7
pubmed: 23792945
Neuropsychopharmacology. 2018 Dec;43(13):2521-2531
pubmed: 30188517
Science. 2020 Apr 10;368(6487):197-201
pubmed: 32273471
Science. 2020 Nov 6;370(6517):660-662
pubmed: 33154125
Neuropharmacology. 2017 Aug 1;122:46-55
pubmed: 28341206
Pharmacol Rev. 2021 Jan;73(1):163-201
pubmed: 33318153
Neuron. 2017 Sep 27;96(1):145-159.e8
pubmed: 28890345
Neuropsychopharmacology. 2021 Jan;46(2):334-342
pubmed: 32417851
Addict Biol. 2019 Sep;24(5):908-920
pubmed: 30022576